Cargando…

A pan-cancer analysis of the oncogenic role of ribonucleotide reductase subunit M2 in human tumors

BACKGROUND: Recent studies have identified ribonucleotide reductase subunit M2 (RRM2) as a putative promoter of tumors. However, no systematic analysis of its carcinogenicity has been conducted. METHODS: The potential functions of RRM2 in various tumor types were investigated using data from the Gen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Yaqun, Fu, Wenhuan, Geng, Zikai, Song, Yun, Yang, Xionggang, He, Tianye, Wu, Jian, Wang, Bin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	PeerJ Inc. 2022
Materias:	Bioinformatics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744174/ https://www.ncbi.nlm.nih.gov/pubmed/36518297 http://dx.doi.org/10.7717/peerj.14432

Ejemplares similares

Ribonucleotide reductase subunit M2 as a novel target for clear-cell renal cell carcinoma
por: Zou, Yun, et al.
Publicado: (2019)

High Expression of Ribonucleotide Reductase Subunit M2 Correlates with Poor Prognosis of Hepatocellular Carcinoma
por: Lee, Boin, et al.
Publicado: (2014)

Targeting the Large Subunit of Human Ribonucleotide Reductase for Cancer Chemotherapy
por: Wijerathna, Sanath R., et al.
Publicado: (2011)

Prognostic and Immunological Potential of Ribonucleotide Reductase Subunits in Liver Cancer
por: Yin, Xin, et al.
Publicado: (2023)

Ribonucleotide reductase subunit switching in hepatoblastoma drug response and relapse
por: Brown, Anthony, et al.
Publicado: (2023)

Prognostic and therapeutic significance of ribonucleotide reductase small subunit M2 in estrogen-negative breast cancers
por: Zhang, Hang, et al.
Publicado: (2014)

Ribonucleotide reductase small subunit M2 is a master driver of aggressive prostate cancer
por: Mazzu, Ying Z., et al.
Publicado: (2020)

In vivo function of the murid herpesvirus-4 ribonucleotide reductase small subunit
por: Milho, Ricardo, et al.
Publicado: (2011)

Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication
por: Foskolou, Iosifina P., et al.
Publicado: (2017)

Differential accumulation of ribonucleotide reductase subunits in clam oocytes: the large subunit is stored as a polypeptide, the small subunit as untranslated mRNA
Publicado: (1986)

Regulation of ribonucleotide reductase M2 expression by the upstream AUGs
por: Dong, Zizheng, et al.
Publicado: (2005)

Ribonucleotide Reductase Subunit M2 Can Be New Molecular Target and Prognostic Biomarker of Hepatocellular Carcinoma
por: Kim, Hee Yeon, et al.
Publicado: (2014)

Sorafenib Inhibits Ribonucleotide Reductase Regulatory Subunit M2 (RRM2) in Hepatocellular Carcinoma Cells
por: Yang, Pei-Ming, et al.
Publicado: (2020)

Regulatory Role of Ribonucleotide Reductase Subunit M2 in Hepatocyte Growth and Pathogenesis of Hepatitis C Virus
por: Kitab, Bouchra, et al.
Publicado: (2023)

Vaccinia Virus–Encoded Ribonucleotide Reductase Subunits Are Differentially Required for Replication and Pathogenesis
por: Gammon, Don B., et al.
Publicado: (2010)

Vasohibin 2 reduces chemosensitivity to gemcitabine in pancreatic cancer cells via Jun proto-oncogene dependent transactivation of ribonucleotide reductase regulatory subunit M2
por: Tu, Min, et al.
Publicado: (2017)

Convergent allostery in ribonucleotide reductase
por: Thomas, William C., et al.
Publicado: (2019)

The periodic table of ribonucleotide reductases
por: Ruskoski, Terry B., et al.
Publicado: (2021)

PanViTa: Pan Virulence and resisTance analysis
por: Rodrigues, Diego Lucas Neres, et al.
Publicado: (2023)

Ribonucleotide reductase small subunit M2 serves as a prognostic biomarker and predicts poor survival of colorectal cancers
por: Liu, Xiyong, et al.
Publicado: (2013)

Screening of traditional Chinese medicine monomers as ribonucleotide reductase M2 inhibitors for tumor treatment
por: Qin, Ya-Ya, et al.
Publicado: (2022)

Downregulation of ribonucleotide reductase subunits M2 induces apoptosis and G1 arrest of cervical cancer cells
por: Wang, Nan, et al.
Publicado: (2018)

Tumor suppressor FOXO3 regulates ribonucleotide reductase subunit RRM2B and impacts on survival of cancer patients
por: Cho, Er-Chieh, et al.
Publicado: (2014)

Ribonucleotide Reductase Inhibitor 3-AP Induces Oncogenic Virus Infected Cell Death and Represses Tumor Growth
por: Dai, Lu, et al.
Publicado: (2018)

Bacillus subtilis Class Ib Ribonucleotide Reductase: High Activity and Dynamic Subunit Interactions
por: Parker, Mackenzie J., et al.
Publicado: (2014)

Ribonucleotide Reductase Large Subunit M1 Predicts Poor Survival Due to Modulation of Proliferative and Invasive Ability of Gastric Cancer
por: Wang, Qinchuan, et al.
Publicado: (2013)

Comprehensive analysis of differentially expressed microRNAs and mRNAs in MDBK cells expressing bovine papillomavirus E5 oncogene
por: Pang, Feng, et al.
Publicado: (2019)

DHS (Trans-4,4’-Dihydroxystilbene) Suppresses DNA Replication and Tumor Growth by Inhibiting RRM2 (Ribonucleotide Reductase Regulatory Subunit M2)
por: Chen, Chi-Wei, et al.
Publicado: (2018)

Ribonucleotide reductase regulatory subunit M2 drives glioblastoma TMZ resistance through modulation of dNTP production
por: Perrault, Ella N., et al.
Publicado: (2023)

The tyrosyl free radical in ribonucleotide reductase.
por: Gräslund, A, et al.
Publicado: (1985)

Subunit and small-molecule interaction of ribonucleotide reductases via surface plasmon resonance biosensor analyses
por: Crona, Mikael, et al.
Publicado: (2010)

Novel ATP-cone-driven allosteric regulation of ribonucleotide reductase via the radical-generating subunit
por: Rozman Grinberg, Inna, et al.
Publicado: (2018)

Functional link between mitochondria and Rnr3, the minor catalytic subunit of yeast ribonucleotide reductase
por: Corcoles-Saez, Isaac, et al.
Publicado: (2019)

Pan‐cancer analyses reveal that increased Hedgehog activity correlates with tumor immunosuppression and resistance to immune checkpoint inhibitors
por: Jiang, Junjie, et al.
Publicado: (2021)

A pan-cancer analysis of prognostic genes
por: Anaya, Jordan, et al.
Publicado: (2016)

Knockdown of ribonucleotide reductase regulatory subunit M2 increases the drug sensitivity of chronic myeloid leukemia to imatinib-based therapy
por: Liu, Chunshui, et al.
Publicado: (2019)

CREB1 directly activates the transcription of ribonucleotide reductase small subunit M2 and promotes the aggressiveness of human colorectal cancer
por: Fang, Zejun, et al.
Publicado: (2016)

Gambogic acid sensitizes gemcitabine efficacy in pancreatic cancer by reducing the expression of ribonucleotide reductase subunit-M2 (RRM2)
por: Xia, Guanggai, et al.
Publicado: (2017)

Ribonucleotide reductase subunits M1 and M2 mRNA expression levels and clinical outcome of lung adenocarcinoma patients treated with docetaxel/gemcitabine
por: Souglakos, J, et al.
Publicado: (2008)

Impact of N221S missense mutation in human ribonucleotide reductase small subunit b on mitochondrial DNA depletion syndrome
por: Su, Leila, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_2i499nj1cbr6mrlcpefing4t62