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Discovery of the SHP2 allosteric inhibitor 2-((3R,4R)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-5-(2,3-dichlorophenyl)-3-methylpyrrolo[2,1-f][1,2,4] triazin-4(3H)-one

The non-receptor protein tyrosine phosphatase (PTP) SHP2 encoded by the PTPN11 gene is a critical regulator in a number of cellular signalling processes and pathways, including the MAPK and the immune-inhibitory programmed cell death PD-L1/PD-1 pathway. Hyperactivation and inactivation of SHP2 is of...

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Detalles Bibliográficos
Autores principales:	Luo, Yanmei, Li, Jin, Zong, Yuliang, Sun, Mengxin, Zheng, Wan, Zhu, Jiapeng, Liu, Liu, Liu, Bing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Brief Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744210/ https://www.ncbi.nlm.nih.gov/pubmed/36476046 http://dx.doi.org/10.1080/14756366.2022.2151594

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