PR-DUB preserves Polycomb repression by preventing excessive accumulation of H2Aub1, an antagonist of chromatin compaction

The Polycomb repressive complexes PRC1, PRC2, and PR-DUB repress target genes by modifying their chromatin. In Drosophila, PRC1 compacts chromatin and monoubiquitinates histone H2A at lysine 118 (H2Aub1), whereas PR-DUB is a major H2Aub1 deubiquitinase, but how H2Aub1 levels must be balanced for Pol...

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Detalles Bibliográficos
Autores principales: Bonnet, Jacques, Boichenko, Iulia, Kalb, Reinhard, Le Jeune, Mathilde, Maltseva, Svetlana, Pieropan, Mattia, Finkl, Katja, Fierz, Beat, Müller, Jürg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744231/
https://www.ncbi.nlm.nih.gov/pubmed/36357125
http://dx.doi.org/10.1101/gad.350014.122

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