Three Cases of Lactic Acidosis Caused by Biguanides

Biguanides may cause lactic acidosis (LA) in elderly patients. We report three cases of LA after the administration of biguanides. Case 1 was an 85-year-old man with no hepatic dysfunction who was discharged, case 2 was a 67-year-old man with no hepatic dysfunction who was discharged, and case 3 was...

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Detalles Bibliográficos
Autores principales: Kuwahara, Masaatsu, Otagaki, Hiroko, Imanaka, Hideaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Endocrinology/Diabetes/Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744419/
https://www.ncbi.nlm.nih.gov/pubmed/36523728
http://dx.doi.org/10.7759/cureus.31419
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author Kuwahara, Masaatsu
Otagaki, Hiroko
Imanaka, Hideaki
author_facet Kuwahara, Masaatsu
Otagaki, Hiroko
Imanaka, Hideaki
author_sort Kuwahara, Masaatsu
collection PubMed
description Biguanides may cause lactic acidosis (LA) in elderly patients. We report three cases of LA after the administration of biguanides. Case 1 was an 85-year-old man with no hepatic dysfunction who was discharged, case 2 was a 67-year-old man with no hepatic dysfunction who was discharged, and case 3 was a 77-year-old woman with hepatic dysfunction who died. Therefore, caution should be exercised in administering biguanides to elderly patients with hepatic dysfunction.
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spelling pubmed-97444192022-12-14 Three Cases of Lactic Acidosis Caused by Biguanides Kuwahara, Masaatsu Otagaki, Hiroko Imanaka, Hideaki Cureus Endocrinology/Diabetes/Metabolism Biguanides may cause lactic acidosis (LA) in elderly patients. We report three cases of LA after the administration of biguanides. Case 1 was an 85-year-old man with no hepatic dysfunction who was discharged, case 2 was a 67-year-old man with no hepatic dysfunction who was discharged, and case 3 was a 77-year-old woman with hepatic dysfunction who died. Therefore, caution should be exercised in administering biguanides to elderly patients with hepatic dysfunction. Cureus 2022-11-12 /pmc/articles/PMC9744419/ /pubmed/36523728 http://dx.doi.org/10.7759/cureus.31419 Text en Copyright © 2022, Kuwahara et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Endocrinology/Diabetes/Metabolism
Kuwahara, Masaatsu
Otagaki, Hiroko
Imanaka, Hideaki
Three Cases of Lactic Acidosis Caused by Biguanides
title Three Cases of Lactic Acidosis Caused by Biguanides
title_full Three Cases of Lactic Acidosis Caused by Biguanides
title_fullStr Three Cases of Lactic Acidosis Caused by Biguanides
title_full_unstemmed Three Cases of Lactic Acidosis Caused by Biguanides
title_short Three Cases of Lactic Acidosis Caused by Biguanides
title_sort three cases of lactic acidosis caused by biguanides
topic Endocrinology/Diabetes/Metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744419/
https://www.ncbi.nlm.nih.gov/pubmed/36523728
http://dx.doi.org/10.7759/cureus.31419
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