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Risk factors for SARS-CoV-2 infection in healthcare workers following an identified nosocomial COVID-19 exposure during waves 1–3 of the pandemic in Ireland

Healthcare workers (HCWs) have increased exposure and subsequent risk of infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). This case-control study was conducted to investigate the contemporaneous risks associated with confirmed SARS-CoV-2 infection amongst HCWs following i...

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Autores principales: McGrath, J., McAloon, C. G., More, S. J., Garrett, S., Reidy, C., Geary, U., Noonan, N., Bergin, C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744455/
https://www.ncbi.nlm.nih.gov/pubmed/36372066
http://dx.doi.org/10.1017/S0950268822001595
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author McGrath, J.
McAloon, C. G.
More, S. J.
Garrett, S.
Reidy, C.
Geary, U.
Noonan, N.
Bergin, C.
author_facet McGrath, J.
McAloon, C. G.
More, S. J.
Garrett, S.
Reidy, C.
Geary, U.
Noonan, N.
Bergin, C.
author_sort McGrath, J.
collection PubMed
description Healthcare workers (HCWs) have increased exposure and subsequent risk of infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). This case-control study was conducted to investigate the contemporaneous risks associated with confirmed SARS-CoV-2 infection amongst HCWs following in-work exposure to a confirmed coronavirus disease-2019 (COVID-19) case. We assessed the influence of demographic (age, sex, nationality, high risk co-morbidities and vaccination status) and work-related factors (job role, exposure location, contact type, personal protective equipment (PPE) use) on infection risk following nosocomial SARS-CoV-2 exposure. All contact tracing records within the hospital site during waves 1–3 of the COVID-19 pandemic in Ireland were screened to identify exposure events, cases and controls. In total, 285 cases and 1526 controls were enrolled, as a result of 1811 in-work exposure events with 745 index cases. We demonstrate that male sex, Eastern European nationality, exposure location, PPE use and vaccination status all impact the likelihood of SARS-CoV-2 infection following nosocomial SARS-CoV-2 exposure. The findings draw attention to the need for continuing emphasis on PPE use and its persisting benefit in the era of COVID-19 vaccinations. We suggest that non-work-related factors may influence infection risk seen in certain ethnic groups and that infection risk in high-risk HCW roles (e.g. nursing) may be the result of repeated exposures rather than risks inherent to a single event.
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spelling pubmed-97444552022-12-13 Risk factors for SARS-CoV-2 infection in healthcare workers following an identified nosocomial COVID-19 exposure during waves 1–3 of the pandemic in Ireland McGrath, J. McAloon, C. G. More, S. J. Garrett, S. Reidy, C. Geary, U. Noonan, N. Bergin, C. Epidemiol Infect Original Paper Healthcare workers (HCWs) have increased exposure and subsequent risk of infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). This case-control study was conducted to investigate the contemporaneous risks associated with confirmed SARS-CoV-2 infection amongst HCWs following in-work exposure to a confirmed coronavirus disease-2019 (COVID-19) case. We assessed the influence of demographic (age, sex, nationality, high risk co-morbidities and vaccination status) and work-related factors (job role, exposure location, contact type, personal protective equipment (PPE) use) on infection risk following nosocomial SARS-CoV-2 exposure. All contact tracing records within the hospital site during waves 1–3 of the COVID-19 pandemic in Ireland were screened to identify exposure events, cases and controls. In total, 285 cases and 1526 controls were enrolled, as a result of 1811 in-work exposure events with 745 index cases. We demonstrate that male sex, Eastern European nationality, exposure location, PPE use and vaccination status all impact the likelihood of SARS-CoV-2 infection following nosocomial SARS-CoV-2 exposure. The findings draw attention to the need for continuing emphasis on PPE use and its persisting benefit in the era of COVID-19 vaccinations. We suggest that non-work-related factors may influence infection risk seen in certain ethnic groups and that infection risk in high-risk HCW roles (e.g. nursing) may be the result of repeated exposures rather than risks inherent to a single event. Cambridge University Press 2021-11-13 /pmc/articles/PMC9744455/ /pubmed/36372066 http://dx.doi.org/10.1017/S0950268822001595 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
spellingShingle Original Paper
McGrath, J.
McAloon, C. G.
More, S. J.
Garrett, S.
Reidy, C.
Geary, U.
Noonan, N.
Bergin, C.
Risk factors for SARS-CoV-2 infection in healthcare workers following an identified nosocomial COVID-19 exposure during waves 1–3 of the pandemic in Ireland
title Risk factors for SARS-CoV-2 infection in healthcare workers following an identified nosocomial COVID-19 exposure during waves 1–3 of the pandemic in Ireland
title_full Risk factors for SARS-CoV-2 infection in healthcare workers following an identified nosocomial COVID-19 exposure during waves 1–3 of the pandemic in Ireland
title_fullStr Risk factors for SARS-CoV-2 infection in healthcare workers following an identified nosocomial COVID-19 exposure during waves 1–3 of the pandemic in Ireland
title_full_unstemmed Risk factors for SARS-CoV-2 infection in healthcare workers following an identified nosocomial COVID-19 exposure during waves 1–3 of the pandemic in Ireland
title_short Risk factors for SARS-CoV-2 infection in healthcare workers following an identified nosocomial COVID-19 exposure during waves 1–3 of the pandemic in Ireland
title_sort risk factors for sars-cov-2 infection in healthcare workers following an identified nosocomial covid-19 exposure during waves 1–3 of the pandemic in ireland
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744455/
https://www.ncbi.nlm.nih.gov/pubmed/36372066
http://dx.doi.org/10.1017/S0950268822001595
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