Prolonged response on olaparib maintenance in metastatic pancreatic acinar cell carcinoma associated with a germline BRCA 2 mutation, revealed by severe panniculitis

This 38‐year‐old man has a familial BRCA2 mutation. He presented with skin erythema, polyarthritis, dactylitis, and febrile erythema nodosum; a biopsy of a liver metastase revealed acinar cell carcinoma of the pancreas. After FOLFIRINOX, olaparib was initiated, and 24 months after, the patient was P...

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Autores principales: Lelong, Margaux, Raoul, Jean‐Luc, Touchefeu, Yann, Berthelot, Jean‐Marie, Arnolfo, Paul, Matysiak‐Budnik, Tamara, Senellart, Hélène
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744715/
https://www.ncbi.nlm.nih.gov/pubmed/36523391
http://dx.doi.org/10.1002/ccr3.6718
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author Lelong, Margaux
Raoul, Jean‐Luc
Touchefeu, Yann
Berthelot, Jean‐Marie
Arnolfo, Paul
Matysiak‐Budnik, Tamara
Senellart, Hélène
author_facet Lelong, Margaux
Raoul, Jean‐Luc
Touchefeu, Yann
Berthelot, Jean‐Marie
Arnolfo, Paul
Matysiak‐Budnik, Tamara
Senellart, Hélène
author_sort Lelong, Margaux
collection PubMed
description This 38‐year‐old man has a familial BRCA2 mutation. He presented with skin erythema, polyarthritis, dactylitis, and febrile erythema nodosum; a biopsy of a liver metastase revealed acinar cell carcinoma of the pancreas. After FOLFIRINOX, olaparib was initiated, and 24 months after, the patient was PS 0 and asymptomatic.
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spelling pubmed-97447152022-12-14 Prolonged response on olaparib maintenance in metastatic pancreatic acinar cell carcinoma associated with a germline BRCA 2 mutation, revealed by severe panniculitis Lelong, Margaux Raoul, Jean‐Luc Touchefeu, Yann Berthelot, Jean‐Marie Arnolfo, Paul Matysiak‐Budnik, Tamara Senellart, Hélène Clin Case Rep Case Report This 38‐year‐old man has a familial BRCA2 mutation. He presented with skin erythema, polyarthritis, dactylitis, and febrile erythema nodosum; a biopsy of a liver metastase revealed acinar cell carcinoma of the pancreas. After FOLFIRINOX, olaparib was initiated, and 24 months after, the patient was PS 0 and asymptomatic. John Wiley and Sons Inc. 2022-12-12 /pmc/articles/PMC9744715/ /pubmed/36523391 http://dx.doi.org/10.1002/ccr3.6718 Text en © 2022 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Report
Lelong, Margaux
Raoul, Jean‐Luc
Touchefeu, Yann
Berthelot, Jean‐Marie
Arnolfo, Paul
Matysiak‐Budnik, Tamara
Senellart, Hélène
Prolonged response on olaparib maintenance in metastatic pancreatic acinar cell carcinoma associated with a germline BRCA 2 mutation, revealed by severe panniculitis
title Prolonged response on olaparib maintenance in metastatic pancreatic acinar cell carcinoma associated with a germline BRCA 2 mutation, revealed by severe panniculitis
title_full Prolonged response on olaparib maintenance in metastatic pancreatic acinar cell carcinoma associated with a germline BRCA 2 mutation, revealed by severe panniculitis
title_fullStr Prolonged response on olaparib maintenance in metastatic pancreatic acinar cell carcinoma associated with a germline BRCA 2 mutation, revealed by severe panniculitis
title_full_unstemmed Prolonged response on olaparib maintenance in metastatic pancreatic acinar cell carcinoma associated with a germline BRCA 2 mutation, revealed by severe panniculitis
title_short Prolonged response on olaparib maintenance in metastatic pancreatic acinar cell carcinoma associated with a germline BRCA 2 mutation, revealed by severe panniculitis
title_sort prolonged response on olaparib maintenance in metastatic pancreatic acinar cell carcinoma associated with a germline brca 2 mutation, revealed by severe panniculitis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744715/
https://www.ncbi.nlm.nih.gov/pubmed/36523391
http://dx.doi.org/10.1002/ccr3.6718
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