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Identifying individuals using proteomics: are we there yet?

Multi-omics approaches including proteomics analyses are becoming an integral component of precision medicine. As clinical proteomics studies gain momentum and their sensitivity increases, research on identifying individuals based on their proteomics data is here examined for risks and ethics-relate...

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Autores principales: Fierro-Monti, Ivo, Wright, James C., Choudhary, Jyoti S., Vizcaíno, Juan Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744771/
https://www.ncbi.nlm.nih.gov/pubmed/36523653
http://dx.doi.org/10.3389/fmolb.2022.1062031
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author Fierro-Monti, Ivo
Wright, James C.
Choudhary, Jyoti S.
Vizcaíno, Juan Antonio
author_facet Fierro-Monti, Ivo
Wright, James C.
Choudhary, Jyoti S.
Vizcaíno, Juan Antonio
author_sort Fierro-Monti, Ivo
collection PubMed
description Multi-omics approaches including proteomics analyses are becoming an integral component of precision medicine. As clinical proteomics studies gain momentum and their sensitivity increases, research on identifying individuals based on their proteomics data is here examined for risks and ethics-related issues. A great deal of work has already been done on this topic for DNA/RNA sequencing data, but it has yet to be widely studied in other omics fields. The current state-of-the-art for the identification of individuals based solely on proteomics data is explained. Protein sequence variation analysis approaches are covered in more detail, including the available analysis workflows and their limitations. We also outline some previous forensic and omics proteomics studies that are relevant for the identification of individuals. Following that, we discuss the risks of patient reidentification using other proteomics data types such as protein expression abundance and post-translational modification (PTM) profiles. In light of the potential identification of individuals through proteomics data, possible legal and ethical implications are becoming increasingly important in the field.
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spelling pubmed-97447712022-12-14 Identifying individuals using proteomics: are we there yet? Fierro-Monti, Ivo Wright, James C. Choudhary, Jyoti S. Vizcaíno, Juan Antonio Front Mol Biosci Molecular Biosciences Multi-omics approaches including proteomics analyses are becoming an integral component of precision medicine. As clinical proteomics studies gain momentum and their sensitivity increases, research on identifying individuals based on their proteomics data is here examined for risks and ethics-related issues. A great deal of work has already been done on this topic for DNA/RNA sequencing data, but it has yet to be widely studied in other omics fields. The current state-of-the-art for the identification of individuals based solely on proteomics data is explained. Protein sequence variation analysis approaches are covered in more detail, including the available analysis workflows and their limitations. We also outline some previous forensic and omics proteomics studies that are relevant for the identification of individuals. Following that, we discuss the risks of patient reidentification using other proteomics data types such as protein expression abundance and post-translational modification (PTM) profiles. In light of the potential identification of individuals through proteomics data, possible legal and ethical implications are becoming increasingly important in the field. Frontiers Media S.A. 2022-11-29 /pmc/articles/PMC9744771/ /pubmed/36523653 http://dx.doi.org/10.3389/fmolb.2022.1062031 Text en Copyright © 2022 Fierro-Monti, Wright, Choudhary and Vizcaíno. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Fierro-Monti, Ivo
Wright, James C.
Choudhary, Jyoti S.
Vizcaíno, Juan Antonio
Identifying individuals using proteomics: are we there yet?
title Identifying individuals using proteomics: are we there yet?
title_full Identifying individuals using proteomics: are we there yet?
title_fullStr Identifying individuals using proteomics: are we there yet?
title_full_unstemmed Identifying individuals using proteomics: are we there yet?
title_short Identifying individuals using proteomics: are we there yet?
title_sort identifying individuals using proteomics: are we there yet?
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744771/
https://www.ncbi.nlm.nih.gov/pubmed/36523653
http://dx.doi.org/10.3389/fmolb.2022.1062031
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