PEAC-seq adopts Prime Editor to detect CRISPR off-target and DNA translocation

CRISPR technology holds significant promise for biological studies and gene therapies because of its high flexibility and efficiency when applied in mammalian cells. But endonuclease (e.g., Cas9) potentially generates undesired edits; thus, there is an urgent need to comprehensively identify off-tar...

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Detalles Bibliográficos
Autores principales: Yu, Zhenxing, Lu, Zhike, Li, Jingjing, Wang, Yingying, Wu, Panfeng, Li, Yini, Zhou, Yangfan, Li, Bailun, Zhang, Heng, Liu, Yingzheng, Ma, Lijia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744820/
https://www.ncbi.nlm.nih.gov/pubmed/36509752
http://dx.doi.org/10.1038/s41467-022-35086-8

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