PRDM1/BLIMP1 induces cancer immune evasion by modulating the USP22-SPI1-PD-L1 axis in hepatocellular carcinoma cells

Programmed death receptor-1 (PD-1) blockade have achieved some efficacy but only in a fraction of patients with hepatocellular carcinoma (HCC). Programmed cell death 1 ligand 1 (PD-L1) binds to its receptor PD1 on T cells to dampen antigen-tumor immune responses. However, the mechanisms underlying P...

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Detalles Bibliográficos
Autores principales: Li, Qing, Zhang, Liren, You, Wenhua, Xu, Jiali, Dai, Jingjing, Hua, Dongxu, Zhang, Ruizhi, Yao, Feifan, Zhou, Suiqing, Huang, Wei, Dai, Yongjiu, Zhang, Yu, Baheti, Tasiken, Qian, Xiaofeng, Pu, Liyong, Xu, Jing, Xia, Yongxiang, Zhang, Chuanyong, Tang, Jinhai, Wang, Xuehao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744896/
https://www.ncbi.nlm.nih.gov/pubmed/36509766
http://dx.doi.org/10.1038/s41467-022-35469-x

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