Case report: CD38-directed CAR-T cell therapy: A novel immunotherapy targeting CD38- positive blasts overcomes TKI and chemotherapy resistance of myeloid chronic myeloid leukemia in blastic phase

Resistance to tyrosine kinase inhibitor (TKI) is a tough problem in the treatment of chronic myeloid leukemia in blastic phase (CML-BP), which was often associated with acquired mutations in the kinase domain and not eliminating the leukemic stem cells. The efficacy of TKI or combination with chemot...

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Detalles Bibliográficos
Autores principales: Cui, Qingya, Liang, Peiqi, Dai, Haiping, Cui, Wei, Cai, Mengjie, Ding, Zixuan, Ma, Qinfen, Yin, Jia, Li, Zheng, Liu, Sining, Kang, Liqing, Yao, Li, Cen, Jiannong, Shen, Hongjie, Zhu, Mingqing, Yu, Lei, Wu, Depei, Tang, Xiaowen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744919/
https://www.ncbi.nlm.nih.gov/pubmed/36524116
http://dx.doi.org/10.3389/fimmu.2022.1012981

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