Cargando…

Reductions in extracellular vesicle-associated microRNA-126 levels in coronary blood after acute myocardial infarction: A retrospective study

BACKGROUND: Acute Myocardial Infarction (AMI) is a kind of cardiovascular disease with high mortality and incidence. Extracellular vesicles (EVs) and microRNA-126 (miR-126) are known to play important role in the development and prognosis of several cardiovascular diseases. Therefore, this study aim...

Descripción completa

Detalles Bibliográficos
Autores principales: Yuan, Yujuan, Ma, Yiping, Aili, Zulipiya, Nijiati, Muyesai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744946/
https://www.ncbi.nlm.nih.gov/pubmed/36523365
http://dx.doi.org/10.3389/fcvm.2022.1046839
_version_ 1784849041787453440
author Yuan, Yujuan
Ma, Yiping
Aili, Zulipiya
Nijiati, Muyesai
author_facet Yuan, Yujuan
Ma, Yiping
Aili, Zulipiya
Nijiati, Muyesai
author_sort Yuan, Yujuan
collection PubMed
description BACKGROUND: Acute Myocardial Infarction (AMI) is a kind of cardiovascular disease with high mortality and incidence. Extracellular vesicles (EVs) and microRNA-126 (miR-126) are known to play important role in the development and prognosis of several cardiovascular diseases. Therefore, this study aimed to investigate the changes in Extracellular vesicle (EV)-associated miR-126 levels in the coronary blood of patients with AMI to explore the relationship between miR-126 levels and AMI. MATERIALS AND METHODS: We analyzed EV-associated miR-126 in the coronary blood of patients with AMI and stable coronary artery disease (SCAD) using quantitative reverse transcription polymerase chain reaction (qRT-PCR). RESULTS: We tested the coronary blood of 20 patients with AMI and 20 with SCAD. The mean age of the patients was 58.8 ± 10.3 years and 32 (80%) were men. We observed that the EV-associated miR-126 levels were lower in patients with AMI [median = 0.13; interquartile range (IQR): 0.08–0.22] than in patients with SCAD (median = 0.37; IQR: 0.26–0.48) (P < 0.001). In addition, the levels of miR-126 were negatively associated with the Thrombolysis in Myocardial Infarction (TIMI) score (r = −0.66, P = 0.001). CONCLUSION: Reduction of EV-associated miR-126 levels in the coronary blood of patients with AMI may be involved in acute coronary thrombosis events.
format Online
Article
Text
id pubmed-9744946
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-97449462022-12-14 Reductions in extracellular vesicle-associated microRNA-126 levels in coronary blood after acute myocardial infarction: A retrospective study Yuan, Yujuan Ma, Yiping Aili, Zulipiya Nijiati, Muyesai Front Cardiovasc Med Cardiovascular Medicine BACKGROUND: Acute Myocardial Infarction (AMI) is a kind of cardiovascular disease with high mortality and incidence. Extracellular vesicles (EVs) and microRNA-126 (miR-126) are known to play important role in the development and prognosis of several cardiovascular diseases. Therefore, this study aimed to investigate the changes in Extracellular vesicle (EV)-associated miR-126 levels in the coronary blood of patients with AMI to explore the relationship between miR-126 levels and AMI. MATERIALS AND METHODS: We analyzed EV-associated miR-126 in the coronary blood of patients with AMI and stable coronary artery disease (SCAD) using quantitative reverse transcription polymerase chain reaction (qRT-PCR). RESULTS: We tested the coronary blood of 20 patients with AMI and 20 with SCAD. The mean age of the patients was 58.8 ± 10.3 years and 32 (80%) were men. We observed that the EV-associated miR-126 levels were lower in patients with AMI [median = 0.13; interquartile range (IQR): 0.08–0.22] than in patients with SCAD (median = 0.37; IQR: 0.26–0.48) (P < 0.001). In addition, the levels of miR-126 were negatively associated with the Thrombolysis in Myocardial Infarction (TIMI) score (r = −0.66, P = 0.001). CONCLUSION: Reduction of EV-associated miR-126 levels in the coronary blood of patients with AMI may be involved in acute coronary thrombosis events. Frontiers Media S.A. 2022-11-29 /pmc/articles/PMC9744946/ /pubmed/36523365 http://dx.doi.org/10.3389/fcvm.2022.1046839 Text en Copyright © 2022 Yuan, Ma, Aili and Nijiati. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Yuan, Yujuan
Ma, Yiping
Aili, Zulipiya
Nijiati, Muyesai
Reductions in extracellular vesicle-associated microRNA-126 levels in coronary blood after acute myocardial infarction: A retrospective study
title Reductions in extracellular vesicle-associated microRNA-126 levels in coronary blood after acute myocardial infarction: A retrospective study
title_full Reductions in extracellular vesicle-associated microRNA-126 levels in coronary blood after acute myocardial infarction: A retrospective study
title_fullStr Reductions in extracellular vesicle-associated microRNA-126 levels in coronary blood after acute myocardial infarction: A retrospective study
title_full_unstemmed Reductions in extracellular vesicle-associated microRNA-126 levels in coronary blood after acute myocardial infarction: A retrospective study
title_short Reductions in extracellular vesicle-associated microRNA-126 levels in coronary blood after acute myocardial infarction: A retrospective study
title_sort reductions in extracellular vesicle-associated microrna-126 levels in coronary blood after acute myocardial infarction: a retrospective study
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744946/
https://www.ncbi.nlm.nih.gov/pubmed/36523365
http://dx.doi.org/10.3389/fcvm.2022.1046839
work_keys_str_mv AT yuanyujuan reductionsinextracellularvesicleassociatedmicrorna126levelsincoronarybloodafteracutemyocardialinfarctionaretrospectivestudy
AT mayiping reductionsinextracellularvesicleassociatedmicrorna126levelsincoronarybloodafteracutemyocardialinfarctionaretrospectivestudy
AT ailizulipiya reductionsinextracellularvesicleassociatedmicrorna126levelsincoronarybloodafteracutemyocardialinfarctionaretrospectivestudy
AT nijiatimuyesai reductionsinextracellularvesicleassociatedmicrorna126levelsincoronarybloodafteracutemyocardialinfarctionaretrospectivestudy