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Cerebellar development after preterm birth
Preterm birth and its complications and the associated adverse factors, including brain hemorrhage, inflammation, and the side effects of medical treatments, are the leading causes of neurodevelopmental disability. Growing evidence suggests that preterm birth affects the cerebellum, which is the bra...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744950/ https://www.ncbi.nlm.nih.gov/pubmed/36523506 http://dx.doi.org/10.3389/fcell.2022.1068288 |
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author | Iskusnykh, Igor Y. Chizhikov, Victor V. |
author_facet | Iskusnykh, Igor Y. Chizhikov, Victor V. |
author_sort | Iskusnykh, Igor Y. |
collection | PubMed |
description | Preterm birth and its complications and the associated adverse factors, including brain hemorrhage, inflammation, and the side effects of medical treatments, are the leading causes of neurodevelopmental disability. Growing evidence suggests that preterm birth affects the cerebellum, which is the brain region involved in motor coordination, cognition, learning, memory, and social communication. The cerebellum is particularly vulnerable to the adverse effects of preterm birth because key cerebellar developmental processes, including the proliferation of neural progenitors, and differentiation and migration of neurons, occur in the third trimester of a human pregnancy. This review discusses the negative impacts of preterm birth and its associated factors on cerebellar development, focusing on the cellular and molecular mechanisms that mediate cerebellar pathology. A better understanding of the cerebellar developmental mechanisms affected by preterm birth is necessary for developing novel treatment and neuroprotective strategies to ameliorate the cognitive, behavioral, and motor deficits experienced by preterm subjects. |
format | Online Article Text |
id | pubmed-9744950 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97449502022-12-14 Cerebellar development after preterm birth Iskusnykh, Igor Y. Chizhikov, Victor V. Front Cell Dev Biol Cell and Developmental Biology Preterm birth and its complications and the associated adverse factors, including brain hemorrhage, inflammation, and the side effects of medical treatments, are the leading causes of neurodevelopmental disability. Growing evidence suggests that preterm birth affects the cerebellum, which is the brain region involved in motor coordination, cognition, learning, memory, and social communication. The cerebellum is particularly vulnerable to the adverse effects of preterm birth because key cerebellar developmental processes, including the proliferation of neural progenitors, and differentiation and migration of neurons, occur in the third trimester of a human pregnancy. This review discusses the negative impacts of preterm birth and its associated factors on cerebellar development, focusing on the cellular and molecular mechanisms that mediate cerebellar pathology. A better understanding of the cerebellar developmental mechanisms affected by preterm birth is necessary for developing novel treatment and neuroprotective strategies to ameliorate the cognitive, behavioral, and motor deficits experienced by preterm subjects. Frontiers Media S.A. 2022-11-29 /pmc/articles/PMC9744950/ /pubmed/36523506 http://dx.doi.org/10.3389/fcell.2022.1068288 Text en Copyright © 2022 Iskusnykh and Chizhikov. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Iskusnykh, Igor Y. Chizhikov, Victor V. Cerebellar development after preterm birth |
title | Cerebellar development after preterm birth |
title_full | Cerebellar development after preterm birth |
title_fullStr | Cerebellar development after preterm birth |
title_full_unstemmed | Cerebellar development after preterm birth |
title_short | Cerebellar development after preterm birth |
title_sort | cerebellar development after preterm birth |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744950/ https://www.ncbi.nlm.nih.gov/pubmed/36523506 http://dx.doi.org/10.3389/fcell.2022.1068288 |
work_keys_str_mv | AT iskusnykhigory cerebellardevelopmentafterpretermbirth AT chizhikovvictorv cerebellardevelopmentafterpretermbirth |