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Restoration of spinal cord injury: From endogenous repairing process to cellular therapy
Spinal cord injury (SCI) disrupts neurological pathways and impacts sensory, motor, and autonomic nerve function. There is no effective treatment for SCI currently. Numerous endogenous cells, including astrocytes, macrophages/microglia, and oligodendrocyte, are involved in the histological healing p...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744968/ https://www.ncbi.nlm.nih.gov/pubmed/36523818 http://dx.doi.org/10.3389/fncel.2022.1077441 |
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author | Wu, Yaqi Tang, Zhijian Zhang, Jun Wang, Yu Liu, Shengwen |
author_facet | Wu, Yaqi Tang, Zhijian Zhang, Jun Wang, Yu Liu, Shengwen |
author_sort | Wu, Yaqi |
collection | PubMed |
description | Spinal cord injury (SCI) disrupts neurological pathways and impacts sensory, motor, and autonomic nerve function. There is no effective treatment for SCI currently. Numerous endogenous cells, including astrocytes, macrophages/microglia, and oligodendrocyte, are involved in the histological healing process following SCI. By interfering with cells during the SCI repair process, some advancements in the therapy of SCI have been realized. Nevertheless, the endogenous cell types engaged in SCI repair and the current difficulties these cells confront in the therapy of SCI are poorly defined, and the mechanisms underlying them are little understood. In order to better understand SCI and create new therapeutic strategies and enhance the clinical translation of SCI repair, we have comprehensively listed the endogenous cells involved in SCI repair and summarized the six most common mechanisms involved in SCI repair, including limiting the inflammatory response, protecting the spared spinal cord, enhancing myelination, facilitating neovascularization, producing neurotrophic factors, and differentiating into neural/colloidal cell lines. |
format | Online Article Text |
id | pubmed-9744968 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97449682022-12-14 Restoration of spinal cord injury: From endogenous repairing process to cellular therapy Wu, Yaqi Tang, Zhijian Zhang, Jun Wang, Yu Liu, Shengwen Front Cell Neurosci Neuroscience Spinal cord injury (SCI) disrupts neurological pathways and impacts sensory, motor, and autonomic nerve function. There is no effective treatment for SCI currently. Numerous endogenous cells, including astrocytes, macrophages/microglia, and oligodendrocyte, are involved in the histological healing process following SCI. By interfering with cells during the SCI repair process, some advancements in the therapy of SCI have been realized. Nevertheless, the endogenous cell types engaged in SCI repair and the current difficulties these cells confront in the therapy of SCI are poorly defined, and the mechanisms underlying them are little understood. In order to better understand SCI and create new therapeutic strategies and enhance the clinical translation of SCI repair, we have comprehensively listed the endogenous cells involved in SCI repair and summarized the six most common mechanisms involved in SCI repair, including limiting the inflammatory response, protecting the spared spinal cord, enhancing myelination, facilitating neovascularization, producing neurotrophic factors, and differentiating into neural/colloidal cell lines. Frontiers Media S.A. 2022-11-29 /pmc/articles/PMC9744968/ /pubmed/36523818 http://dx.doi.org/10.3389/fncel.2022.1077441 Text en Copyright © 2022 Wu, Tang, Zhang, Wang and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Wu, Yaqi Tang, Zhijian Zhang, Jun Wang, Yu Liu, Shengwen Restoration of spinal cord injury: From endogenous repairing process to cellular therapy |
title | Restoration of spinal cord injury: From endogenous repairing process to cellular therapy |
title_full | Restoration of spinal cord injury: From endogenous repairing process to cellular therapy |
title_fullStr | Restoration of spinal cord injury: From endogenous repairing process to cellular therapy |
title_full_unstemmed | Restoration of spinal cord injury: From endogenous repairing process to cellular therapy |
title_short | Restoration of spinal cord injury: From endogenous repairing process to cellular therapy |
title_sort | restoration of spinal cord injury: from endogenous repairing process to cellular therapy |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744968/ https://www.ncbi.nlm.nih.gov/pubmed/36523818 http://dx.doi.org/10.3389/fncel.2022.1077441 |
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