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Restoration of spinal cord injury: From endogenous repairing process to cellular therapy

Spinal cord injury (SCI) disrupts neurological pathways and impacts sensory, motor, and autonomic nerve function. There is no effective treatment for SCI currently. Numerous endogenous cells, including astrocytes, macrophages/microglia, and oligodendrocyte, are involved in the histological healing p...

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Autores principales: Wu, Yaqi, Tang, Zhijian, Zhang, Jun, Wang, Yu, Liu, Shengwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744968/
https://www.ncbi.nlm.nih.gov/pubmed/36523818
http://dx.doi.org/10.3389/fncel.2022.1077441
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author Wu, Yaqi
Tang, Zhijian
Zhang, Jun
Wang, Yu
Liu, Shengwen
author_facet Wu, Yaqi
Tang, Zhijian
Zhang, Jun
Wang, Yu
Liu, Shengwen
author_sort Wu, Yaqi
collection PubMed
description Spinal cord injury (SCI) disrupts neurological pathways and impacts sensory, motor, and autonomic nerve function. There is no effective treatment for SCI currently. Numerous endogenous cells, including astrocytes, macrophages/microglia, and oligodendrocyte, are involved in the histological healing process following SCI. By interfering with cells during the SCI repair process, some advancements in the therapy of SCI have been realized. Nevertheless, the endogenous cell types engaged in SCI repair and the current difficulties these cells confront in the therapy of SCI are poorly defined, and the mechanisms underlying them are little understood. In order to better understand SCI and create new therapeutic strategies and enhance the clinical translation of SCI repair, we have comprehensively listed the endogenous cells involved in SCI repair and summarized the six most common mechanisms involved in SCI repair, including limiting the inflammatory response, protecting the spared spinal cord, enhancing myelination, facilitating neovascularization, producing neurotrophic factors, and differentiating into neural/colloidal cell lines.
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spelling pubmed-97449682022-12-14 Restoration of spinal cord injury: From endogenous repairing process to cellular therapy Wu, Yaqi Tang, Zhijian Zhang, Jun Wang, Yu Liu, Shengwen Front Cell Neurosci Neuroscience Spinal cord injury (SCI) disrupts neurological pathways and impacts sensory, motor, and autonomic nerve function. There is no effective treatment for SCI currently. Numerous endogenous cells, including astrocytes, macrophages/microglia, and oligodendrocyte, are involved in the histological healing process following SCI. By interfering with cells during the SCI repair process, some advancements in the therapy of SCI have been realized. Nevertheless, the endogenous cell types engaged in SCI repair and the current difficulties these cells confront in the therapy of SCI are poorly defined, and the mechanisms underlying them are little understood. In order to better understand SCI and create new therapeutic strategies and enhance the clinical translation of SCI repair, we have comprehensively listed the endogenous cells involved in SCI repair and summarized the six most common mechanisms involved in SCI repair, including limiting the inflammatory response, protecting the spared spinal cord, enhancing myelination, facilitating neovascularization, producing neurotrophic factors, and differentiating into neural/colloidal cell lines. Frontiers Media S.A. 2022-11-29 /pmc/articles/PMC9744968/ /pubmed/36523818 http://dx.doi.org/10.3389/fncel.2022.1077441 Text en Copyright © 2022 Wu, Tang, Zhang, Wang and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Wu, Yaqi
Tang, Zhijian
Zhang, Jun
Wang, Yu
Liu, Shengwen
Restoration of spinal cord injury: From endogenous repairing process to cellular therapy
title Restoration of spinal cord injury: From endogenous repairing process to cellular therapy
title_full Restoration of spinal cord injury: From endogenous repairing process to cellular therapy
title_fullStr Restoration of spinal cord injury: From endogenous repairing process to cellular therapy
title_full_unstemmed Restoration of spinal cord injury: From endogenous repairing process to cellular therapy
title_short Restoration of spinal cord injury: From endogenous repairing process to cellular therapy
title_sort restoration of spinal cord injury: from endogenous repairing process to cellular therapy
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744968/
https://www.ncbi.nlm.nih.gov/pubmed/36523818
http://dx.doi.org/10.3389/fncel.2022.1077441
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