Lymphopenia during (177)Lu-DOTATATE therapy leading to recurrence of tuberculosis: a case report

We report the case of a 72-year-old woman who presented with tuberculous arthritis during the setting of (177)Lu-DOTATATE therapy for a grade-2 neuro-endocrine pancreatic tumor with liver metastases. We hypothesized that this recurrence might have been related to the occurrence of lymphopenia, which...

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Autores principales: Boughdad, Sarah, Da Mota, Michael, Mendes De Carvalho, Mélanie, Firsova, Maria, Prior, John O., Schaefer, Niklaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744994/
https://www.ncbi.nlm.nih.gov/pubmed/36510100
http://dx.doi.org/10.1186/s41824-022-00157-y
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author Boughdad, Sarah
Da Mota, Michael
Mendes De Carvalho, Mélanie
Firsova, Maria
Prior, John O.
Schaefer, Niklaus
author_facet Boughdad, Sarah
Da Mota, Michael
Mendes De Carvalho, Mélanie
Firsova, Maria
Prior, John O.
Schaefer, Niklaus
author_sort Boughdad, Sarah
collection PubMed
description We report the case of a 72-year-old woman who presented with tuberculous arthritis during the setting of (177)Lu-DOTATATE therapy for a grade-2 neuro-endocrine pancreatic tumor with liver metastases. We hypothesized that this recurrence might have been related to the occurrence of lymphopenia, which is common during PRRT. Indeed, though lymphopenia is frequently dismissed, it could lead to the development of opportunistic diseases and its severity should be examined, especially in case of abnormal clinical symptoms. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s41824-022-00157-y.
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spelling pubmed-97449942022-12-14 Lymphopenia during (177)Lu-DOTATATE therapy leading to recurrence of tuberculosis: a case report Boughdad, Sarah Da Mota, Michael Mendes De Carvalho, Mélanie Firsova, Maria Prior, John O. Schaefer, Niklaus Eur J Hybrid Imaging Case Report We report the case of a 72-year-old woman who presented with tuberculous arthritis during the setting of (177)Lu-DOTATATE therapy for a grade-2 neuro-endocrine pancreatic tumor with liver metastases. We hypothesized that this recurrence might have been related to the occurrence of lymphopenia, which is common during PRRT. Indeed, though lymphopenia is frequently dismissed, it could lead to the development of opportunistic diseases and its severity should be examined, especially in case of abnormal clinical symptoms. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s41824-022-00157-y. Springer International Publishing 2022-12-13 /pmc/articles/PMC9744994/ /pubmed/36510100 http://dx.doi.org/10.1186/s41824-022-00157-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Case Report
Boughdad, Sarah
Da Mota, Michael
Mendes De Carvalho, Mélanie
Firsova, Maria
Prior, John O.
Schaefer, Niklaus
Lymphopenia during (177)Lu-DOTATATE therapy leading to recurrence of tuberculosis: a case report
title Lymphopenia during (177)Lu-DOTATATE therapy leading to recurrence of tuberculosis: a case report
title_full Lymphopenia during (177)Lu-DOTATATE therapy leading to recurrence of tuberculosis: a case report
title_fullStr Lymphopenia during (177)Lu-DOTATATE therapy leading to recurrence of tuberculosis: a case report
title_full_unstemmed Lymphopenia during (177)Lu-DOTATATE therapy leading to recurrence of tuberculosis: a case report
title_short Lymphopenia during (177)Lu-DOTATATE therapy leading to recurrence of tuberculosis: a case report
title_sort lymphopenia during (177)lu-dotatate therapy leading to recurrence of tuberculosis: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744994/
https://www.ncbi.nlm.nih.gov/pubmed/36510100
http://dx.doi.org/10.1186/s41824-022-00157-y
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