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Skeletal muscle metabolism and contraction performance regulation by teneurin C-terminal-associated peptide-1
Skeletal muscle regulation is responsible for voluntary muscular movement in vertebrates. The genes of two essential proteins, teneurins and latrophilins (LPHN), evolving in ancestors of multicellular animals form a ligand-receptor pair, and are now shown to be required for skeletal muscle function....
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9745124/ https://www.ncbi.nlm.nih.gov/pubmed/36523555 http://dx.doi.org/10.3389/fphys.2022.1031264 |
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author | Hogg, David W. Reid, Andrea L. Dodsworth, Thomas L. Chen, Yani Reid, Ross M. Xu, Mei Husic, Mia Biga, Peggy R. Slee, Andrew Buck, Leslie T. Barsyte-Lovejoy, Dalia Locke, Marius Lovejoy, David A. |
author_facet | Hogg, David W. Reid, Andrea L. Dodsworth, Thomas L. Chen, Yani Reid, Ross M. Xu, Mei Husic, Mia Biga, Peggy R. Slee, Andrew Buck, Leslie T. Barsyte-Lovejoy, Dalia Locke, Marius Lovejoy, David A. |
author_sort | Hogg, David W. |
collection | PubMed |
description | Skeletal muscle regulation is responsible for voluntary muscular movement in vertebrates. The genes of two essential proteins, teneurins and latrophilins (LPHN), evolving in ancestors of multicellular animals form a ligand-receptor pair, and are now shown to be required for skeletal muscle function. Teneurins possess a bioactive peptide, termed the teneurin C-terminal associated peptide (TCAP) that interacts with the LPHNs to regulate skeletal muscle contractility strength and fatigue by an insulin-independent glucose importation mechanism in rats. CRISPR-based knockouts and siRNA-associated knockdowns of LPHN-1 and-3 in the C2C12 mouse skeletal cell line shows that TCAP stimulates an LPHN-dependent cytosolic Ca(2+) signal transduction cascade to increase energy metabolism and enhance skeletal muscle function via increases in type-1 oxidative fiber formation and reduce the fatigue response. Thus, the teneurin/TCAP-LPHN system is presented as a novel mechanism that regulates the energy requirements and performance of skeletal muscle. |
format | Online Article Text |
id | pubmed-9745124 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97451242022-12-14 Skeletal muscle metabolism and contraction performance regulation by teneurin C-terminal-associated peptide-1 Hogg, David W. Reid, Andrea L. Dodsworth, Thomas L. Chen, Yani Reid, Ross M. Xu, Mei Husic, Mia Biga, Peggy R. Slee, Andrew Buck, Leslie T. Barsyte-Lovejoy, Dalia Locke, Marius Lovejoy, David A. Front Physiol Physiology Skeletal muscle regulation is responsible for voluntary muscular movement in vertebrates. The genes of two essential proteins, teneurins and latrophilins (LPHN), evolving in ancestors of multicellular animals form a ligand-receptor pair, and are now shown to be required for skeletal muscle function. Teneurins possess a bioactive peptide, termed the teneurin C-terminal associated peptide (TCAP) that interacts with the LPHNs to regulate skeletal muscle contractility strength and fatigue by an insulin-independent glucose importation mechanism in rats. CRISPR-based knockouts and siRNA-associated knockdowns of LPHN-1 and-3 in the C2C12 mouse skeletal cell line shows that TCAP stimulates an LPHN-dependent cytosolic Ca(2+) signal transduction cascade to increase energy metabolism and enhance skeletal muscle function via increases in type-1 oxidative fiber formation and reduce the fatigue response. Thus, the teneurin/TCAP-LPHN system is presented as a novel mechanism that regulates the energy requirements and performance of skeletal muscle. Frontiers Media S.A. 2022-11-29 /pmc/articles/PMC9745124/ /pubmed/36523555 http://dx.doi.org/10.3389/fphys.2022.1031264 Text en Copyright © 2022 Hogg, Reid, Dodsworth, Chen, Reid, Xu, Husic, Biga, Slee, Buck, Barsyte-Lovejoy, Locke and Lovejoy. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Hogg, David W. Reid, Andrea L. Dodsworth, Thomas L. Chen, Yani Reid, Ross M. Xu, Mei Husic, Mia Biga, Peggy R. Slee, Andrew Buck, Leslie T. Barsyte-Lovejoy, Dalia Locke, Marius Lovejoy, David A. Skeletal muscle metabolism and contraction performance regulation by teneurin C-terminal-associated peptide-1 |
title | Skeletal muscle metabolism and contraction performance regulation by teneurin C-terminal-associated peptide-1 |
title_full | Skeletal muscle metabolism and contraction performance regulation by teneurin C-terminal-associated peptide-1 |
title_fullStr | Skeletal muscle metabolism and contraction performance regulation by teneurin C-terminal-associated peptide-1 |
title_full_unstemmed | Skeletal muscle metabolism and contraction performance regulation by teneurin C-terminal-associated peptide-1 |
title_short | Skeletal muscle metabolism and contraction performance regulation by teneurin C-terminal-associated peptide-1 |
title_sort | skeletal muscle metabolism and contraction performance regulation by teneurin c-terminal-associated peptide-1 |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9745124/ https://www.ncbi.nlm.nih.gov/pubmed/36523555 http://dx.doi.org/10.3389/fphys.2022.1031264 |
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