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Key brain cell interactions and contributions to the pathogenesis of Alzheimer’s disease
Alzheimer’s disease (AD) is the most common neurodegenerative disease worldwide, with the two major hallmarks being the deposition of extracellular β-amyloid (Aβ) plaques and of intracellular neurofibrillary tangles (NFTs). Additionally, early pathological events such as cerebrovascular alterations,...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9745159/ https://www.ncbi.nlm.nih.gov/pubmed/36523504 http://dx.doi.org/10.3389/fcell.2022.1036123 |
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author | Saavedra, Joana Nascimento, Mariana Liz, Márcia A. Cardoso, Isabel |
author_facet | Saavedra, Joana Nascimento, Mariana Liz, Márcia A. Cardoso, Isabel |
author_sort | Saavedra, Joana |
collection | PubMed |
description | Alzheimer’s disease (AD) is the most common neurodegenerative disease worldwide, with the two major hallmarks being the deposition of extracellular β-amyloid (Aβ) plaques and of intracellular neurofibrillary tangles (NFTs). Additionally, early pathological events such as cerebrovascular alterations, a compromised blood-brain barrier (BBB) integrity, neuroinflammation and synaptic dysfunction, culminate in neuron loss and cognitive deficits. AD symptoms reflect a loss of neuronal circuit integrity in the brain; however, neurons do not operate in isolation. An exclusively neurocentric approach is insufficient to understand this disease, and the contribution of other brain cells including astrocytes, microglia, and vascular cells must be integrated in the context. The delicate balance of interactions between these cells, required for healthy brain function, is disrupted during disease. To design successful therapies, it is critical to understand the complex brain cellular connections in AD and the temporal sequence of their disturbance. In this review, we discuss the interactions between different brain cells, from physiological conditions to their pathological reactions in AD, and how this basic knowledge can be crucial for developing new therapeutic strategies. |
format | Online Article Text |
id | pubmed-9745159 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97451592022-12-14 Key brain cell interactions and contributions to the pathogenesis of Alzheimer’s disease Saavedra, Joana Nascimento, Mariana Liz, Márcia A. Cardoso, Isabel Front Cell Dev Biol Cell and Developmental Biology Alzheimer’s disease (AD) is the most common neurodegenerative disease worldwide, with the two major hallmarks being the deposition of extracellular β-amyloid (Aβ) plaques and of intracellular neurofibrillary tangles (NFTs). Additionally, early pathological events such as cerebrovascular alterations, a compromised blood-brain barrier (BBB) integrity, neuroinflammation and synaptic dysfunction, culminate in neuron loss and cognitive deficits. AD symptoms reflect a loss of neuronal circuit integrity in the brain; however, neurons do not operate in isolation. An exclusively neurocentric approach is insufficient to understand this disease, and the contribution of other brain cells including astrocytes, microglia, and vascular cells must be integrated in the context. The delicate balance of interactions between these cells, required for healthy brain function, is disrupted during disease. To design successful therapies, it is critical to understand the complex brain cellular connections in AD and the temporal sequence of their disturbance. In this review, we discuss the interactions between different brain cells, from physiological conditions to their pathological reactions in AD, and how this basic knowledge can be crucial for developing new therapeutic strategies. Frontiers Media S.A. 2022-11-29 /pmc/articles/PMC9745159/ /pubmed/36523504 http://dx.doi.org/10.3389/fcell.2022.1036123 Text en Copyright © 2022 Saavedra, Nascimento, Liz and Cardoso. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Saavedra, Joana Nascimento, Mariana Liz, Márcia A. Cardoso, Isabel Key brain cell interactions and contributions to the pathogenesis of Alzheimer’s disease |
title | Key brain cell interactions and contributions to the pathogenesis of Alzheimer’s disease |
title_full | Key brain cell interactions and contributions to the pathogenesis of Alzheimer’s disease |
title_fullStr | Key brain cell interactions and contributions to the pathogenesis of Alzheimer’s disease |
title_full_unstemmed | Key brain cell interactions and contributions to the pathogenesis of Alzheimer’s disease |
title_short | Key brain cell interactions and contributions to the pathogenesis of Alzheimer’s disease |
title_sort | key brain cell interactions and contributions to the pathogenesis of alzheimer’s disease |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9745159/ https://www.ncbi.nlm.nih.gov/pubmed/36523504 http://dx.doi.org/10.3389/fcell.2022.1036123 |
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