Visible light-promoted transition metal-free direct C3-carbamoylation of 2H-Indazoles

We reported a general transition metal-free transformation to access C3-carbamoylated 2H-indazoles via visible light-induced oxidative decarboxylation coupling, in the presence of oxamic acids as the coupling sources, 4CzIPN as the photocatalyst, and Cs(2)CO(3) as the base. The great application pot...

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Detalles Bibliográficos
Autores principales: Ma, Chunhua, Shang, Linchun, Zhao, Hanying, He, Xing, Lv, Qiyan, Zhang, Dandan, Jiang, Yuqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9745185/
https://www.ncbi.nlm.nih.gov/pubmed/36523748
http://dx.doi.org/10.3389/fchem.2022.1087834
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author Ma, Chunhua
Shang, Linchun
Zhao, Hanying
He, Xing
Lv, Qiyan
Zhang, Dandan
Jiang, Yuqin
author_facet Ma, Chunhua
Shang, Linchun
Zhao, Hanying
He, Xing
Lv, Qiyan
Zhang, Dandan
Jiang, Yuqin
author_sort Ma, Chunhua
collection PubMed
description We reported a general transition metal-free transformation to access C3-carbamoylated 2H-indazoles via visible light-induced oxidative decarboxylation coupling, in the presence of oxamic acids as the coupling sources, 4CzIPN as the photocatalyst, and Cs(2)CO(3) as the base. The great application potential of this mild condition is highlighted by the late-stage modification of drugs, N-terminal modification of peptides, and the good antitumor activity of the novel desired product.
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spelling pubmed-97451852022-12-14 Visible light-promoted transition metal-free direct C3-carbamoylation of 2H-Indazoles Ma, Chunhua Shang, Linchun Zhao, Hanying He, Xing Lv, Qiyan Zhang, Dandan Jiang, Yuqin Front Chem Chemistry We reported a general transition metal-free transformation to access C3-carbamoylated 2H-indazoles via visible light-induced oxidative decarboxylation coupling, in the presence of oxamic acids as the coupling sources, 4CzIPN as the photocatalyst, and Cs(2)CO(3) as the base. The great application potential of this mild condition is highlighted by the late-stage modification of drugs, N-terminal modification of peptides, and the good antitumor activity of the novel desired product. Frontiers Media S.A. 2022-11-29 /pmc/articles/PMC9745185/ /pubmed/36523748 http://dx.doi.org/10.3389/fchem.2022.1087834 Text en Copyright © 2022 Ma, Shang, Zhao, He, Lv, Zhang and Jiang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Ma, Chunhua
Shang, Linchun
Zhao, Hanying
He, Xing
Lv, Qiyan
Zhang, Dandan
Jiang, Yuqin
Visible light-promoted transition metal-free direct C3-carbamoylation of 2H-Indazoles
title Visible light-promoted transition metal-free direct C3-carbamoylation of 2H-Indazoles
title_full Visible light-promoted transition metal-free direct C3-carbamoylation of 2H-Indazoles
title_fullStr Visible light-promoted transition metal-free direct C3-carbamoylation of 2H-Indazoles
title_full_unstemmed Visible light-promoted transition metal-free direct C3-carbamoylation of 2H-Indazoles
title_short Visible light-promoted transition metal-free direct C3-carbamoylation of 2H-Indazoles
title_sort visible light-promoted transition metal-free direct c3-carbamoylation of 2h-indazoles
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9745185/
https://www.ncbi.nlm.nih.gov/pubmed/36523748
http://dx.doi.org/10.3389/fchem.2022.1087834
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