Mutations matter: An observational study of the prognostic and predictive value of KRAS mutations in metastatic colorectal cancer

BACKGROUND: About half of metastatic colorectal cancers (CRCs) harbor Rat Sarcoma (RAS) activating mutations as oncogenic driver, but the prognostic role of RAS mutations is not fully elucidated. Interestingly, specific hotspot mutations have been identified as potential candidates for novel targete...

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Detalles Bibliográficos
Autores principales: Lavacchi, Daniele, Fancelli, Sara, Roviello, Giandomenico, Castiglione, Francesca, Caliman, Enrico, Rossi, Gemma, Venturini, Jacopo, Pellegrini, Elisa, Brugia, Marco, Vannini, Agnese, Bartoli, Caterina, Cianchi, Fabio, Pillozzi, Serena, Antonuzzo, Lorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9745189/
https://www.ncbi.nlm.nih.gov/pubmed/36523988
http://dx.doi.org/10.3389/fonc.2022.1055019

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