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SARS-CoV-2 Prevalence in Malawi Based on Data from Survey of Communities and Health Workers in 5 High-Burden Districts, October 2020

To determine early COVID-19 burden in Malawi, we conducted a multistage cluster survey in 5 districts. During October–December 2020, we recruited 5,010 community members (median age 32 years, interquartile range 21–43 years) and 1,021 health facility staff (HFS) (median age 35 years, interquartile r...

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Autores principales: Theu, Joe Alex, Kabaghe, Alinune Nathanael, Bello, George, Chitsa-Banda, Evelyn, Kagoli, Matthews, Auld, Andrew, Mkungudza, Jonathan, O’Malley, Gabrielle, Bangara, Fred Fredrick, Peacocke, Elizabeth F., Babaye, Yusuf, Ng’ambi, Wingston, Saussier, Christel, MacLachlan, Ellen, Chapotera, Gertrude, Phiri, Mphatso Dennis, Kim, Evelyn, Chiwaula, Mabvuto, Payne, Danielle, Wadonda-Kabondo, Nellie, Chauma-Mwale, Annie, Divala, Titus Henry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9745213/
https://www.ncbi.nlm.nih.gov/pubmed/36502413
http://dx.doi.org/10.3201/eid2813.212348
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author Theu, Joe Alex
Kabaghe, Alinune Nathanael
Bello, George
Chitsa-Banda, Evelyn
Kagoli, Matthews
Auld, Andrew
Mkungudza, Jonathan
O’Malley, Gabrielle
Bangara, Fred Fredrick
Peacocke, Elizabeth F.
Babaye, Yusuf
Ng’ambi, Wingston
Saussier, Christel
MacLachlan, Ellen
Chapotera, Gertrude
Phiri, Mphatso Dennis
Kim, Evelyn
Chiwaula, Mabvuto
Payne, Danielle
Wadonda-Kabondo, Nellie
Chauma-Mwale, Annie
Divala, Titus Henry
author_facet Theu, Joe Alex
Kabaghe, Alinune Nathanael
Bello, George
Chitsa-Banda, Evelyn
Kagoli, Matthews
Auld, Andrew
Mkungudza, Jonathan
O’Malley, Gabrielle
Bangara, Fred Fredrick
Peacocke, Elizabeth F.
Babaye, Yusuf
Ng’ambi, Wingston
Saussier, Christel
MacLachlan, Ellen
Chapotera, Gertrude
Phiri, Mphatso Dennis
Kim, Evelyn
Chiwaula, Mabvuto
Payne, Danielle
Wadonda-Kabondo, Nellie
Chauma-Mwale, Annie
Divala, Titus Henry
author_sort Theu, Joe Alex
collection PubMed
description To determine early COVID-19 burden in Malawi, we conducted a multistage cluster survey in 5 districts. During October–December 2020, we recruited 5,010 community members (median age 32 years, interquartile range 21–43 years) and 1,021 health facility staff (HFS) (median age 35 years, interquartile range 28–43 years). Real-time PCR–confirmed SARS-CoV-2 infection prevalence was 0.3% (95% CI 0.2%–0.5%) among community and 0.5% (95% CI 0.1%–1.2%) among HFS participants; seroprevalence was 7.8% (95% CI 6.3%–9.6%) among community and 9.7% (95% CI 6.4%–14.5%) among HFS participants. Most seropositive community (84.7%) and HFS (76.0%) participants were asymptomatic. Seroprevalence was higher among urban community (12.6% vs. 3.1%) and HFS (14.5% vs. 7.4%) than among rural community participants. Cumulative infection findings 113-fold higher from this survey than national statistics (486,771 vs. 4,319) and predominantly asymptomatic infections highlight a need to identify alternative surveillance approaches and predictors of severe disease to inform national response.
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spelling pubmed-97452132022-12-19 SARS-CoV-2 Prevalence in Malawi Based on Data from Survey of Communities and Health Workers in 5 High-Burden Districts, October 2020 Theu, Joe Alex Kabaghe, Alinune Nathanael Bello, George Chitsa-Banda, Evelyn Kagoli, Matthews Auld, Andrew Mkungudza, Jonathan O’Malley, Gabrielle Bangara, Fred Fredrick Peacocke, Elizabeth F. Babaye, Yusuf Ng’ambi, Wingston Saussier, Christel MacLachlan, Ellen Chapotera, Gertrude Phiri, Mphatso Dennis Kim, Evelyn Chiwaula, Mabvuto Payne, Danielle Wadonda-Kabondo, Nellie Chauma-Mwale, Annie Divala, Titus Henry Emerg Infect Dis Surveillance, Information, and Laboratory Systems To determine early COVID-19 burden in Malawi, we conducted a multistage cluster survey in 5 districts. During October–December 2020, we recruited 5,010 community members (median age 32 years, interquartile range 21–43 years) and 1,021 health facility staff (HFS) (median age 35 years, interquartile range 28–43 years). Real-time PCR–confirmed SARS-CoV-2 infection prevalence was 0.3% (95% CI 0.2%–0.5%) among community and 0.5% (95% CI 0.1%–1.2%) among HFS participants; seroprevalence was 7.8% (95% CI 6.3%–9.6%) among community and 9.7% (95% CI 6.4%–14.5%) among HFS participants. Most seropositive community (84.7%) and HFS (76.0%) participants were asymptomatic. Seroprevalence was higher among urban community (12.6% vs. 3.1%) and HFS (14.5% vs. 7.4%) than among rural community participants. Cumulative infection findings 113-fold higher from this survey than national statistics (486,771 vs. 4,319) and predominantly asymptomatic infections highlight a need to identify alternative surveillance approaches and predictors of severe disease to inform national response. Centers for Disease Control and Prevention 2022-12 /pmc/articles/PMC9745213/ /pubmed/36502413 http://dx.doi.org/10.3201/eid2813.212348 Text en https://creativecommons.org/licenses/by/4.0/Emerging Infectious Diseases is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Surveillance, Information, and Laboratory Systems
Theu, Joe Alex
Kabaghe, Alinune Nathanael
Bello, George
Chitsa-Banda, Evelyn
Kagoli, Matthews
Auld, Andrew
Mkungudza, Jonathan
O’Malley, Gabrielle
Bangara, Fred Fredrick
Peacocke, Elizabeth F.
Babaye, Yusuf
Ng’ambi, Wingston
Saussier, Christel
MacLachlan, Ellen
Chapotera, Gertrude
Phiri, Mphatso Dennis
Kim, Evelyn
Chiwaula, Mabvuto
Payne, Danielle
Wadonda-Kabondo, Nellie
Chauma-Mwale, Annie
Divala, Titus Henry
SARS-CoV-2 Prevalence in Malawi Based on Data from Survey of Communities and Health Workers in 5 High-Burden Districts, October 2020
title SARS-CoV-2 Prevalence in Malawi Based on Data from Survey of Communities and Health Workers in 5 High-Burden Districts, October 2020
title_full SARS-CoV-2 Prevalence in Malawi Based on Data from Survey of Communities and Health Workers in 5 High-Burden Districts, October 2020
title_fullStr SARS-CoV-2 Prevalence in Malawi Based on Data from Survey of Communities and Health Workers in 5 High-Burden Districts, October 2020
title_full_unstemmed SARS-CoV-2 Prevalence in Malawi Based on Data from Survey of Communities and Health Workers in 5 High-Burden Districts, October 2020
title_short SARS-CoV-2 Prevalence in Malawi Based on Data from Survey of Communities and Health Workers in 5 High-Burden Districts, October 2020
title_sort sars-cov-2 prevalence in malawi based on data from survey of communities and health workers in 5 high-burden districts, october 2020
topic Surveillance, Information, and Laboratory Systems
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9745213/
https://www.ncbi.nlm.nih.gov/pubmed/36502413
http://dx.doi.org/10.3201/eid2813.212348
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