The impact of aging on intestinal mucosal immune function and clinical applications

Immune cells and immune molecules in the intestinal mucosa participate in innate and adaptive immunity to maintain local and systematic homeostasis. With aging, intestinal mucosal immune dysfunction will promote the emergence of age-associated diseases. Although there have been a number of studies o...

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Autores principales: Zheng, Han, Zhang, Chi, Wang, Qianqian, Feng, Shuyan, Fang, Yi, Zhang, Shuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9745321/
https://www.ncbi.nlm.nih.gov/pubmed/36524122
http://dx.doi.org/10.3389/fimmu.2022.1029948
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author Zheng, Han
Zhang, Chi
Wang, Qianqian
Feng, Shuyan
Fang, Yi
Zhang, Shuo
author_facet Zheng, Han
Zhang, Chi
Wang, Qianqian
Feng, Shuyan
Fang, Yi
Zhang, Shuo
author_sort Zheng, Han
collection PubMed
description Immune cells and immune molecules in the intestinal mucosa participate in innate and adaptive immunity to maintain local and systematic homeostasis. With aging, intestinal mucosal immune dysfunction will promote the emergence of age-associated diseases. Although there have been a number of studies on the impact of aging on systemic immunity, relatively fewer studies have been conducted on the impact of aging on the intestinal mucosal immune system. In this review, we will briefly introduce the impact of aging on the intestinal mucosal barrier, the impact of aging on intestinal immune cells as well as immune molecules, and the process of interaction between intestinal mucosal immunity and gut microbiota during aging. After that we will discuss potential strategies to slow down intestinal aging in the elderly.
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spelling pubmed-97453212022-12-14 The impact of aging on intestinal mucosal immune function and clinical applications Zheng, Han Zhang, Chi Wang, Qianqian Feng, Shuyan Fang, Yi Zhang, Shuo Front Immunol Immunology Immune cells and immune molecules in the intestinal mucosa participate in innate and adaptive immunity to maintain local and systematic homeostasis. With aging, intestinal mucosal immune dysfunction will promote the emergence of age-associated diseases. Although there have been a number of studies on the impact of aging on systemic immunity, relatively fewer studies have been conducted on the impact of aging on the intestinal mucosal immune system. In this review, we will briefly introduce the impact of aging on the intestinal mucosal barrier, the impact of aging on intestinal immune cells as well as immune molecules, and the process of interaction between intestinal mucosal immunity and gut microbiota during aging. After that we will discuss potential strategies to slow down intestinal aging in the elderly. Frontiers Media S.A. 2022-11-28 /pmc/articles/PMC9745321/ /pubmed/36524122 http://dx.doi.org/10.3389/fimmu.2022.1029948 Text en Copyright © 2022 Zheng, Zhang, Wang, Feng, Fang and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zheng, Han
Zhang, Chi
Wang, Qianqian
Feng, Shuyan
Fang, Yi
Zhang, Shuo
The impact of aging on intestinal mucosal immune function and clinical applications
title The impact of aging on intestinal mucosal immune function and clinical applications
title_full The impact of aging on intestinal mucosal immune function and clinical applications
title_fullStr The impact of aging on intestinal mucosal immune function and clinical applications
title_full_unstemmed The impact of aging on intestinal mucosal immune function and clinical applications
title_short The impact of aging on intestinal mucosal immune function and clinical applications
title_sort impact of aging on intestinal mucosal immune function and clinical applications
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9745321/
https://www.ncbi.nlm.nih.gov/pubmed/36524122
http://dx.doi.org/10.3389/fimmu.2022.1029948
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