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Physical Activity and Exercise Promote Peroxisome Proliferator-Activated Receptor Gamma Expression in Adipose Tissues of Obese Adults

BACKGROUND: Peroxisome proliferator-activated receptor gamma (PPARγ) has recently been studied for its potential influence on the functional response of the human body to exercise. We aimed to investigate the association of habitual physical activity (PA) with PPARγ mRNA level in the visceral and su...

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Autores principales: Zarkesh, Maryam, Nozhat, Zahra, Akbarzadeh, Mahdi, Daneshpour, Maryam, Mahmoodi, Behnaz, Asghari, Golaleh, Hedayati, Mehdi, Daneshafrooz, Afsoon, Fedoruk, Rani, Yuzbashian, Emad, Mirmiran, Parvin, Khalaj, Alireza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9745396/
https://www.ncbi.nlm.nih.gov/pubmed/36561261
http://dx.doi.org/10.18502/ijph.v51i11.11181
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author Zarkesh, Maryam
Nozhat, Zahra
Akbarzadeh, Mahdi
Daneshpour, Maryam
Mahmoodi, Behnaz
Asghari, Golaleh
Hedayati, Mehdi
Daneshafrooz, Afsoon
Fedoruk, Rani
Yuzbashian, Emad
Mirmiran, Parvin
Khalaj, Alireza
author_facet Zarkesh, Maryam
Nozhat, Zahra
Akbarzadeh, Mahdi
Daneshpour, Maryam
Mahmoodi, Behnaz
Asghari, Golaleh
Hedayati, Mehdi
Daneshafrooz, Afsoon
Fedoruk, Rani
Yuzbashian, Emad
Mirmiran, Parvin
Khalaj, Alireza
author_sort Zarkesh, Maryam
collection PubMed
description BACKGROUND: Peroxisome proliferator-activated receptor gamma (PPARγ) has recently been studied for its potential influence on the functional response of the human body to exercise. We aimed to investigate the association of habitual physical activity (PA) with PPARγ mRNA level in the visceral and subcutaneous adipose tissues (VAT and SAT) in non-obese and obese non-diabetic adults. METHODS: VAT and SAT were obtained from 95 individuals, including 40 non-obese (BMI<30kg/m(2)) and 55 obese (BMI≥30kg/m(2)) who underwent elective abdominal surgery (Tehran, Iran, 2012–2015). The assessment of habitual PA was performed by a valid and reliable International PA Questionnaire-long form, and the metabolic equivalent of task (MET) was evaluated. Real-time quantitative reverse transcriptase-PCR evaluated the PPARγ expression in VAT and SAT. RESULTS: PPARγ expression in both VAT (1.18 vs. 0.37 fold change, P<0.001) and SAT (2.07 vs. 0.29 fold change, P=0.004) among obese subjects was higher than the non-obese group. After controlling for age, sex, and total energy in-take, a positive association was found between total METs and PPARγ expression in both VAT and SAT among obese participants (β=0.22, P=0.007 and β=0.12, P<0.001, respectively). Among obese participants, there was a direct association between leisure time-related METs with VAT PPARγ expression (β=0.05, P=0.026). Moreover, in this group, an association was observed between occupation-related METs with PPARγ in both fat tissues (β=0.11, P=0.002 and β=0.17, P=0.013, respectively), and household work-related METs with SAT PPARγ (β=0.21, P=0.011). CONCLUSION: High PA as an indispensable part of a healthy lifestyle may exert its beneficial effect by regulating PPARγ expression.
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spelling pubmed-97453962022-12-21 Physical Activity and Exercise Promote Peroxisome Proliferator-Activated Receptor Gamma Expression in Adipose Tissues of Obese Adults Zarkesh, Maryam Nozhat, Zahra Akbarzadeh, Mahdi Daneshpour, Maryam Mahmoodi, Behnaz Asghari, Golaleh Hedayati, Mehdi Daneshafrooz, Afsoon Fedoruk, Rani Yuzbashian, Emad Mirmiran, Parvin Khalaj, Alireza Iran J Public Health Original Article BACKGROUND: Peroxisome proliferator-activated receptor gamma (PPARγ) has recently been studied for its potential influence on the functional response of the human body to exercise. We aimed to investigate the association of habitual physical activity (PA) with PPARγ mRNA level in the visceral and subcutaneous adipose tissues (VAT and SAT) in non-obese and obese non-diabetic adults. METHODS: VAT and SAT were obtained from 95 individuals, including 40 non-obese (BMI<30kg/m(2)) and 55 obese (BMI≥30kg/m(2)) who underwent elective abdominal surgery (Tehran, Iran, 2012–2015). The assessment of habitual PA was performed by a valid and reliable International PA Questionnaire-long form, and the metabolic equivalent of task (MET) was evaluated. Real-time quantitative reverse transcriptase-PCR evaluated the PPARγ expression in VAT and SAT. RESULTS: PPARγ expression in both VAT (1.18 vs. 0.37 fold change, P<0.001) and SAT (2.07 vs. 0.29 fold change, P=0.004) among obese subjects was higher than the non-obese group. After controlling for age, sex, and total energy in-take, a positive association was found between total METs and PPARγ expression in both VAT and SAT among obese participants (β=0.22, P=0.007 and β=0.12, P<0.001, respectively). Among obese participants, there was a direct association between leisure time-related METs with VAT PPARγ expression (β=0.05, P=0.026). Moreover, in this group, an association was observed between occupation-related METs with PPARγ in both fat tissues (β=0.11, P=0.002 and β=0.17, P=0.013, respectively), and household work-related METs with SAT PPARγ (β=0.21, P=0.011). CONCLUSION: High PA as an indispensable part of a healthy lifestyle may exert its beneficial effect by regulating PPARγ expression. Tehran University of Medical Sciences 2022-11 /pmc/articles/PMC9745396/ /pubmed/36561261 http://dx.doi.org/10.18502/ijph.v51i11.11181 Text en Copyright © 2022 Zarkesh et al. Published by Tehran University of Medical Sciences https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International license (https://creativecommons.org/licenses/by-nc/4.0/). Non-commercial uses of the work are permitted, provided the original work is properly cited.
spellingShingle Original Article
Zarkesh, Maryam
Nozhat, Zahra
Akbarzadeh, Mahdi
Daneshpour, Maryam
Mahmoodi, Behnaz
Asghari, Golaleh
Hedayati, Mehdi
Daneshafrooz, Afsoon
Fedoruk, Rani
Yuzbashian, Emad
Mirmiran, Parvin
Khalaj, Alireza
Physical Activity and Exercise Promote Peroxisome Proliferator-Activated Receptor Gamma Expression in Adipose Tissues of Obese Adults
title Physical Activity and Exercise Promote Peroxisome Proliferator-Activated Receptor Gamma Expression in Adipose Tissues of Obese Adults
title_full Physical Activity and Exercise Promote Peroxisome Proliferator-Activated Receptor Gamma Expression in Adipose Tissues of Obese Adults
title_fullStr Physical Activity and Exercise Promote Peroxisome Proliferator-Activated Receptor Gamma Expression in Adipose Tissues of Obese Adults
title_full_unstemmed Physical Activity and Exercise Promote Peroxisome Proliferator-Activated Receptor Gamma Expression in Adipose Tissues of Obese Adults
title_short Physical Activity and Exercise Promote Peroxisome Proliferator-Activated Receptor Gamma Expression in Adipose Tissues of Obese Adults
title_sort physical activity and exercise promote peroxisome proliferator-activated receptor gamma expression in adipose tissues of obese adults
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9745396/
https://www.ncbi.nlm.nih.gov/pubmed/36561261
http://dx.doi.org/10.18502/ijph.v51i11.11181
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