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A clinical risk model for assessing the survival of patients with stage IA–IIA non-small cell lung cancer after surgery
BACKGROUND: The survival of patients with stage IA–IIA non-small cell lung cancer (NSCLC) after surgery is heterogeneous. This study aimed to construct a prognostic risk model to predict the overall survival (OS) of these patients. METHODS: Data from patients (n=9,914) from the Surveillance Epidemio...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9745515/ https://www.ncbi.nlm.nih.gov/pubmed/36524081 http://dx.doi.org/10.21037/jtd-22-890 |
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author | Qian, Jia-Yi Li, Zhi-Xin Wu, Lei-Lei Song, Si-Hui Li, Chong-Wu Lin, Wei-Kang Xu, Shu-Quan Li, Kun Xie, Dong |
author_facet | Qian, Jia-Yi Li, Zhi-Xin Wu, Lei-Lei Song, Si-Hui Li, Chong-Wu Lin, Wei-Kang Xu, Shu-Quan Li, Kun Xie, Dong |
author_sort | Qian, Jia-Yi |
collection | PubMed |
description | BACKGROUND: The survival of patients with stage IA–IIA non-small cell lung cancer (NSCLC) after surgery is heterogeneous. This study aimed to construct a prognostic risk model to predict the overall survival (OS) of these patients. METHODS: Data from patients (n=9,914) from the Surveillance Epidemiology and End Results (SEER) database were analyzed. The cases were randomly divided into the training and the validation groups. Patients from the Shanghai Pulmonary Hospital (n=270) were also included as an external cohort. Independent significant factors affecting survival in the training cohort were used to construct a nomogram. The precision was evaluated using the concordance index (C-index) and calibration plots. The X-tile software was used to confirm the optimal cut-off value to classify the patients. RESULTS: Sex, age at diagnosis, tumor size, visceral pleura invasion (VPI), tumor grade, and the number of examined lymph nodes were deemed independent prognostic factors and were selected to establish the nomogram. The C-indices of the nomogram for predicting OS were 0.671 [95% confidence interval (CI): 0.653–0.689] in the training group, and 0.668 (95% CI: 0.650–0.687) and 0.707 (95% CI: 0.651–0.763) in the validation and the testing groups, respectively. The cut-off value of risk points was 106.0, which stratified the patients into high-risk and low-risk groups. The high-risk patients had shorter 5-year OS than low-risk patients (P<0.001). CONCLUSIONS: The established nomogram could evaluate the survival in patients with stage IA–IIA NSCLC after surgery and may provide prognostic information for clinicians to make decisions in the management of adjuvant therapy. |
format | Online Article Text |
id | pubmed-9745515 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-97455152022-12-14 A clinical risk model for assessing the survival of patients with stage IA–IIA non-small cell lung cancer after surgery Qian, Jia-Yi Li, Zhi-Xin Wu, Lei-Lei Song, Si-Hui Li, Chong-Wu Lin, Wei-Kang Xu, Shu-Quan Li, Kun Xie, Dong J Thorac Dis Original Article BACKGROUND: The survival of patients with stage IA–IIA non-small cell lung cancer (NSCLC) after surgery is heterogeneous. This study aimed to construct a prognostic risk model to predict the overall survival (OS) of these patients. METHODS: Data from patients (n=9,914) from the Surveillance Epidemiology and End Results (SEER) database were analyzed. The cases were randomly divided into the training and the validation groups. Patients from the Shanghai Pulmonary Hospital (n=270) were also included as an external cohort. Independent significant factors affecting survival in the training cohort were used to construct a nomogram. The precision was evaluated using the concordance index (C-index) and calibration plots. The X-tile software was used to confirm the optimal cut-off value to classify the patients. RESULTS: Sex, age at diagnosis, tumor size, visceral pleura invasion (VPI), tumor grade, and the number of examined lymph nodes were deemed independent prognostic factors and were selected to establish the nomogram. The C-indices of the nomogram for predicting OS were 0.671 [95% confidence interval (CI): 0.653–0.689] in the training group, and 0.668 (95% CI: 0.650–0.687) and 0.707 (95% CI: 0.651–0.763) in the validation and the testing groups, respectively. The cut-off value of risk points was 106.0, which stratified the patients into high-risk and low-risk groups. The high-risk patients had shorter 5-year OS than low-risk patients (P<0.001). CONCLUSIONS: The established nomogram could evaluate the survival in patients with stage IA–IIA NSCLC after surgery and may provide prognostic information for clinicians to make decisions in the management of adjuvant therapy. AME Publishing Company 2022-11 /pmc/articles/PMC9745515/ /pubmed/36524081 http://dx.doi.org/10.21037/jtd-22-890 Text en 2022 Journal of Thoracic Disease. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Original Article Qian, Jia-Yi Li, Zhi-Xin Wu, Lei-Lei Song, Si-Hui Li, Chong-Wu Lin, Wei-Kang Xu, Shu-Quan Li, Kun Xie, Dong A clinical risk model for assessing the survival of patients with stage IA–IIA non-small cell lung cancer after surgery |
title | A clinical risk model for assessing the survival of patients with stage IA–IIA non-small cell lung cancer after surgery |
title_full | A clinical risk model for assessing the survival of patients with stage IA–IIA non-small cell lung cancer after surgery |
title_fullStr | A clinical risk model for assessing the survival of patients with stage IA–IIA non-small cell lung cancer after surgery |
title_full_unstemmed | A clinical risk model for assessing the survival of patients with stage IA–IIA non-small cell lung cancer after surgery |
title_short | A clinical risk model for assessing the survival of patients with stage IA–IIA non-small cell lung cancer after surgery |
title_sort | clinical risk model for assessing the survival of patients with stage ia–iia non-small cell lung cancer after surgery |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9745515/ https://www.ncbi.nlm.nih.gov/pubmed/36524081 http://dx.doi.org/10.21037/jtd-22-890 |
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