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Temporal trends in disease-specific causes of cardiovascular mortality amongst patients with cancer in the USA between 1999 and 2019
AIMS: We report disease-specific cardiovascular causes of mortality among cancer patients in the USA between 1999 and 2019, considering temporal trends by age, sex, and cancer site. METHODS AND RESULTS: We used the Multiple Cause of Death database, accessed through the Centers for Disease Control an...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9745666/ https://www.ncbi.nlm.nih.gov/pubmed/35435219 http://dx.doi.org/10.1093/ehjqcco/qcac016 |
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author | Raisi-Estabragh, Zahra Kobo, Ofer Freeman, Phillip Petersen, Steffen E Kolman, Louis Miller, Robert J H Roguin, Ariel Van Spall, Harriette G C Vuong, Jacqueline Yang, Eric H Mamas, Mamas A |
author_facet | Raisi-Estabragh, Zahra Kobo, Ofer Freeman, Phillip Petersen, Steffen E Kolman, Louis Miller, Robert J H Roguin, Ariel Van Spall, Harriette G C Vuong, Jacqueline Yang, Eric H Mamas, Mamas A |
author_sort | Raisi-Estabragh, Zahra |
collection | PubMed |
description | AIMS: We report disease-specific cardiovascular causes of mortality among cancer patients in the USA between 1999 and 2019, considering temporal trends by age, sex, and cancer site. METHODS AND RESULTS: We used the Multiple Cause of Death database, accessed through the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research resource. We included 629 308 decedents with cardiovascular disease (CVD) recorded as the primary cause of death and active malignancy listed as a contributing cause of death. We created disease-specific CVD categories and grouped cancers by site. We calculated the proportion of CVD deaths attributed to each disease category stratified by sex, age, and cancer site. We also examined disease-specific temporal trends by cancer site. Ischaemic heart disease (IHD) was the most common cardiovascular cause of death across all cancer types (55.6%), being more common in men (59.8%), older ages, and in those with lung (67.8%) and prostate (58.3%) cancers. Cerebrovascular disease (12.9%) and hypertensive diseases (7.6%) were other common causes of death. The proportion of deaths due to heart failure was greatest in haematological (7.7%) and breast (6.3%) cancers. There was a decreasing temporal trend in the proportion of cardiovascular deaths attributed to IHD across all cancer types. The proportion of deaths due to hypertensive diseases showed the greatest percentage increase, with the largest change in breast cancer patients (+191.1%). CONCLUSION: We demonstrate differential cardiovascular mortality risk by cancer site and demographics, providing insight into the evolving healthcare needs of this growing high-cardiovascular risk population. |
format | Online Article Text |
id | pubmed-9745666 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-97456662022-12-13 Temporal trends in disease-specific causes of cardiovascular mortality amongst patients with cancer in the USA between 1999 and 2019 Raisi-Estabragh, Zahra Kobo, Ofer Freeman, Phillip Petersen, Steffen E Kolman, Louis Miller, Robert J H Roguin, Ariel Van Spall, Harriette G C Vuong, Jacqueline Yang, Eric H Mamas, Mamas A Eur Heart J Qual Care Clin Outcomes Original Article AIMS: We report disease-specific cardiovascular causes of mortality among cancer patients in the USA between 1999 and 2019, considering temporal trends by age, sex, and cancer site. METHODS AND RESULTS: We used the Multiple Cause of Death database, accessed through the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research resource. We included 629 308 decedents with cardiovascular disease (CVD) recorded as the primary cause of death and active malignancy listed as a contributing cause of death. We created disease-specific CVD categories and grouped cancers by site. We calculated the proportion of CVD deaths attributed to each disease category stratified by sex, age, and cancer site. We also examined disease-specific temporal trends by cancer site. Ischaemic heart disease (IHD) was the most common cardiovascular cause of death across all cancer types (55.6%), being more common in men (59.8%), older ages, and in those with lung (67.8%) and prostate (58.3%) cancers. Cerebrovascular disease (12.9%) and hypertensive diseases (7.6%) were other common causes of death. The proportion of deaths due to heart failure was greatest in haematological (7.7%) and breast (6.3%) cancers. There was a decreasing temporal trend in the proportion of cardiovascular deaths attributed to IHD across all cancer types. The proportion of deaths due to hypertensive diseases showed the greatest percentage increase, with the largest change in breast cancer patients (+191.1%). CONCLUSION: We demonstrate differential cardiovascular mortality risk by cancer site and demographics, providing insight into the evolving healthcare needs of this growing high-cardiovascular risk population. Oxford University Press 2022-04-18 /pmc/articles/PMC9745666/ /pubmed/35435219 http://dx.doi.org/10.1093/ehjqcco/qcac016 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Raisi-Estabragh, Zahra Kobo, Ofer Freeman, Phillip Petersen, Steffen E Kolman, Louis Miller, Robert J H Roguin, Ariel Van Spall, Harriette G C Vuong, Jacqueline Yang, Eric H Mamas, Mamas A Temporal trends in disease-specific causes of cardiovascular mortality amongst patients with cancer in the USA between 1999 and 2019 |
title | Temporal trends in disease-specific causes of cardiovascular mortality amongst patients with cancer in the USA between 1999 and 2019 |
title_full | Temporal trends in disease-specific causes of cardiovascular mortality amongst patients with cancer in the USA between 1999 and 2019 |
title_fullStr | Temporal trends in disease-specific causes of cardiovascular mortality amongst patients with cancer in the USA between 1999 and 2019 |
title_full_unstemmed | Temporal trends in disease-specific causes of cardiovascular mortality amongst patients with cancer in the USA between 1999 and 2019 |
title_short | Temporal trends in disease-specific causes of cardiovascular mortality amongst patients with cancer in the USA between 1999 and 2019 |
title_sort | temporal trends in disease-specific causes of cardiovascular mortality amongst patients with cancer in the usa between 1999 and 2019 |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9745666/ https://www.ncbi.nlm.nih.gov/pubmed/35435219 http://dx.doi.org/10.1093/ehjqcco/qcac016 |
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