Cargando…

A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Phase 2b Trial of P2X3 Receptor Antagonist Sivopixant for Refractory or Unexplained Chronic Cough

INTRODUCTION: To determine the optimal dose of sivopixant, a highly selective P2X3 receptor antagonist, for refractory or unexplained chronic cough (RCC/UCC). METHODS: In this phase 2b, randomized, double-blind, placebo-controlled, parallel-group, multicenter trial, patients received sivopixant 50,...

Descripción completa

Detalles Bibliográficos
Autores principales:	McGarvey, Lorcan, Smith, Jaclyn A., Morice, Alyn, Birring, Surinder S., Chung, Kian Fan, Dicpinigaitis, Peter V., Niimi, Akio, Benninger, Michael S., Sher, Mandel, Matsunaga, Yuko, Miyazaki, Sayaka, Machida, Mitsuaki, Ishihara, Hiroyuki, Mahmood, Adnan, Gomez, Juan-Carlos
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2022
Materias:	Cough
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9745691/ https://www.ncbi.nlm.nih.gov/pubmed/36512069 http://dx.doi.org/10.1007/s00408-022-00592-5

Ejemplares similares

Characterization of Patients With Refractory or Unexplained Chronic Cough Participating in a Phase 2 Clinical Trial of the P2X3-Receptor Antagonist Gefapixant
por: Morice, Alyn H., et al.
Publicado: (2021)

Improvements in Objective and Subjective Measures of Chronic Cough with Gefapixant: A Pooled Phase 3 Efficacy Analysis of Predefined Subgroups
por: Smith, Jaclyn A., et al.
Publicado: (2022)

Efficacy and Safety of Eliapixant in Refractory Chronic Cough: The Randomized, Placebo-Controlled Phase 2b PAGANINI Study
por: Dicpinigaitis, Peter V., et al.
Publicado: (2023)

Chronic cough: new insights and future prospects
por: Morice, Alyn, et al.
Publicado: (2021)

The Efficacy and Safety of Gefapixant in a Phase 3b Trial of Patients with Recent-Onset Chronic Cough
por: McGarvey, Lorcan, et al.
Publicado: (2023)

Validation and Meaningful Change Thresholds for an Objective Cough Frequency Measurement in Chronic Cough
por: Schelfhout, Jonathan, et al.
Publicado: (2022)

Treating acute cough: wet versus dry – have we got the paradigm wrong?
por: Morice, Alyn H., et al.
Publicado: (2015)

Sound: a non-invasive measure of cough intensity
por: Lee, Kai K, et al.
Publicado: (2017)

Objective and Subjective Measurement of Cough in Asthma: A Systematic Review of the Literature
por: Holmes, Joshua, et al.
Publicado: (2022)

Design and rationale of two phase 3 randomised controlled trials (COUGH-1 and COUGH-2) of gefapixant, a P2X3 receptor antagonist, in refractory or unexplained chronic cough
por: Muccino, David R., et al.
Publicado: (2020)

Comprehensive evidence-based review on European antitussives
por: Morice, Alyn, et al.
Publicado: (2016)

Efficacy and Safety of Gefapixant for Refractory or Unexplained Chronic Cough over 52 Weeks
por: Birring, Surinder S., et al.
Publicado: (2023)

Randomised trial of the P2X(3) receptor antagonist sivopixant for refractory chronic cough
por: Niimi, Akio, et al.
Publicado: (2022)

Effect of aclidinium bromide on cough and sputum symptoms in moderate-to-severe COPD in three phase III trials
por: McGarvey, Lorcan, et al.
Publicado: (2016)

Domiciliary Cough Monitoring for the Prediction of COPD Exacerbations
por: Crooks, Michael G., et al.
Publicado: (2021)

The Relationship Between Cough Reflex Sensitivity and Exacerbation Frequency in Chronic Obstructive Pulmonary Disease
por: Cho, Peter S. P., et al.
Publicado: (2020)

Cough Characteristics and Healthcare Journeys of Chronic Cough Patients in Community-Based Populations in South Korea and Taiwan
por: Song, Woo-Jung, et al.
Publicado: (2022)

CT airway remodelling and chronic cough
por: Abozid, Hazim, et al.
Publicado: (2023)

Cough in the Elderly During the COVID-19 Pandemic
por: Kaulamo, Johanna Tuulikki, et al.
Publicado: (2022)

Recurrent Cough in the Elderly: A Forgotten Entity
por: Kaulamo, Johanna Tuulikki, et al.
Publicado: (2023)

From bench to bedside: The role of cough hypersensitivity in chronic cough
por: Drake, Matthew G., et al.
Publicado: (2023)

Reply to Weinberger
por: Birring, Surinder S., et al.
Publicado: (2023)

Cough Sensitivity to Several External Triggers is Associated with Multiple Non-respiratory Symptoms
por: Koskela, Heikki O., et al.
Publicado: (2023)

Web-based survey to evaluate the prevalence of chronic and subacute cough and patient characteristics in Japan
por: Tobe, Keisuke, et al.
Publicado: (2021)

Healthcare-Seeking Behaviour Due to Cough in Finnish Elderly: Too Much and Too Little
por: Kaulamo, Johanna Tuulikki, et al.
Publicado: (2023)

Characteristics and Management of Patients with Refractory or Unexplained Chronic Cough in Outpatient Hospital Clinics in Spain: A Retrospective Multicenter Study
por: Dávila, Ignacio, et al.
Publicado: (2023)

A Survey of Physicians' Perception of the Use and Effectiveness of Diagnostic and Therapeutic Procedures in Chronic Cough Patients
por: Puente-Maestu, Luis, et al.
Publicado: (2021)

Cough hypersensitivity and chronic cough
por: Chung, Kian Fan, et al.
Publicado: (2022)

The Effect of Aclidinium on Symptoms Including Cough in Chronic Obstructive Pulmonary Disease: A Phase 4, Double-Blind, Placebo-controlled, Parallel-Group Study
por: Smith, Jaclyn A., et al.
Publicado: (2019)

Disease burden and quality of life of patients with chronic cough in Japan: a population-based cross-sectional survey
por: Kubo, Takekazu, et al.
Publicado: (2021)

Self-reported symptoms of chronic cough and breathlessness in working-age men in the city of Izhevsk, Russia: associations with cardiovascular disease risk factors and comorbidities
por: Cook, Sarah, et al.
Publicado: (2015)

Measuring cough: what really matters?
por: Turner, Richard Douglas, et al.
Publicado: (2023)

Mechanisms and Rationale for Targeted Therapies in Refractory and Unexplained Chronic Cough
por: Mazzone, Stuart B., et al.
Publicado: (2020)

Eliapixant (BAY 1817080), a P2X3 receptor antagonist, in refractory chronic cough: a randomised, placebo-controlled, crossover phase 2a study
por: Morice, Alyn, et al.
Publicado: (2021)

Chronic cough—the limitation and advances in assessment techniques
por: Zhang, Mengru, et al.
Publicado: (2022)

Consensus goals and standards for specialist cough clinics: the NEUROCOUGH international Delphi study
por: Song, Woo-Jung, et al.
Publicado: (2023)

Adaptive study design to assess effect of TRPV4 inhibition in patients with chronic cough
por: Ludbrook, Valerie J., et al.
Publicado: (2021)

An observational study to determine the relationship between cough frequency and markers of inflammation in severe asthma
por: Holmes, Joshua, et al.
Publicado: (2022)

The present and future of cough counting tools
por: Hall, Jocelin Isabel, et al.
Publicado: (2020)

The P2X3 receptor antagonist filapixant in patients with refractory chronic cough: a randomized controlled trial
por: Friedrich, Christian, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_isj16c8f0ch80otlrt2n1micgl