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A Rare Case of Cardiac Metastasis from Colon Cancer
It is very rare for colorectal neoplasms to metastasize to the heart in the worldwide medical literature; only a single case of well-documented colorectal cancer metastasis to the left atrium was found. The case of a 66-year-old man is explained in this paper, who was suffering from metastatic adeno...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Iranian Society of Pathology
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9745759/ https://www.ncbi.nlm.nih.gov/pubmed/36532640 http://dx.doi.org/10.30699/IJP.2022.551822.2874 |
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author | Modabber, Zahra Pourkia, Roghayeh Vafaey, Hamidreza Alizadeh, Ali Ranaee, Mohammad |
author_facet | Modabber, Zahra Pourkia, Roghayeh Vafaey, Hamidreza Alizadeh, Ali Ranaee, Mohammad |
author_sort | Modabber, Zahra |
collection | PubMed |
description | It is very rare for colorectal neoplasms to metastasize to the heart in the worldwide medical literature; only a single case of well-documented colorectal cancer metastasis to the left atrium was found. The case of a 66-year-old man is explained in this paper, who was suffering from metastatic adenocarcinoma of the colon that included the left atrium. In transthoracic and transesophageal echocardiography, a large multilobulated mass was present in the left atrium. An accidental pulmonary mass was also seen in a lung spiral CT scan. The cardiac mass was taken out, and a biopsy was obtained from the pulmonary mass. Adenocarcinoma was seen in histological assessment. Immunohistochemical staining was carried out to examine the expression of cytokeratin 7, cytokeratin 20, and caudal-related homeobox transcription factor 2 (CDX2) to determine the origin of the adenocarcinoma. In addition, the expression of these proteins was linked to the attributes of the patient and tumor. Post-surgical transesophageal echocardiography showed normal left ventricle and right ventricle function with no evidence of left atrium mass. Therefore, we suggest that asymptomatic cancer patients with a history of colorectal cancer and who have developed cardiac symptoms should be immediately examined for potential cardiac metastasis. |
format | Online Article Text |
id | pubmed-9745759 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Iranian Society of Pathology |
record_format | MEDLINE/PubMed |
spelling | pubmed-97457592022-12-16 A Rare Case of Cardiac Metastasis from Colon Cancer Modabber, Zahra Pourkia, Roghayeh Vafaey, Hamidreza Alizadeh, Ali Ranaee, Mohammad Iran J Pathol Case Report It is very rare for colorectal neoplasms to metastasize to the heart in the worldwide medical literature; only a single case of well-documented colorectal cancer metastasis to the left atrium was found. The case of a 66-year-old man is explained in this paper, who was suffering from metastatic adenocarcinoma of the colon that included the left atrium. In transthoracic and transesophageal echocardiography, a large multilobulated mass was present in the left atrium. An accidental pulmonary mass was also seen in a lung spiral CT scan. The cardiac mass was taken out, and a biopsy was obtained from the pulmonary mass. Adenocarcinoma was seen in histological assessment. Immunohistochemical staining was carried out to examine the expression of cytokeratin 7, cytokeratin 20, and caudal-related homeobox transcription factor 2 (CDX2) to determine the origin of the adenocarcinoma. In addition, the expression of these proteins was linked to the attributes of the patient and tumor. Post-surgical transesophageal echocardiography showed normal left ventricle and right ventricle function with no evidence of left atrium mass. Therefore, we suggest that asymptomatic cancer patients with a history of colorectal cancer and who have developed cardiac symptoms should be immediately examined for potential cardiac metastasis. Iranian Society of Pathology 2022 2022-08-02 /pmc/articles/PMC9745759/ /pubmed/36532640 http://dx.doi.org/10.30699/IJP.2022.551822.2874 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution- 4.0 International License (https://creativecommons.org/licenses/by/4.0/) which permits Share, copy and redistribution of the material in any medium or format or adapt, remix, transform, and build upon the material for any purpose, even commercially. |
spellingShingle | Case Report Modabber, Zahra Pourkia, Roghayeh Vafaey, Hamidreza Alizadeh, Ali Ranaee, Mohammad A Rare Case of Cardiac Metastasis from Colon Cancer |
title | A Rare Case of Cardiac Metastasis from Colon Cancer |
title_full | A Rare Case of Cardiac Metastasis from Colon Cancer |
title_fullStr | A Rare Case of Cardiac Metastasis from Colon Cancer |
title_full_unstemmed | A Rare Case of Cardiac Metastasis from Colon Cancer |
title_short | A Rare Case of Cardiac Metastasis from Colon Cancer |
title_sort | rare case of cardiac metastasis from colon cancer |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9745759/ https://www.ncbi.nlm.nih.gov/pubmed/36532640 http://dx.doi.org/10.30699/IJP.2022.551822.2874 |
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