Epstein-Barr Virus Glycoprotein Antibody Titers and Risk of Nasopharyngeal Carcinoma

We evaluated antibody against Epstein-Barr virus glycoproteins (gp350, gH/gL, gB, gp42) in 97 nasopharyngeal carcinoma (NPC) cases and 97 cancer-free controls. Each unit increase in log-transformed antibody against gp350 and gH/gL was associated with 2.27 (95% confidence interval [CI], 1.20–4.29) an...

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Autores principales: Coghill, Anna E, McGuire, Andrew, Sinha, Sweta, Homad, Leah, Sinha, Irika, Sholukh, Anton, Koh, Woon-Puay, Yuan, Jian Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9745775/
https://www.ncbi.nlm.nih.gov/pubmed/36519117
http://dx.doi.org/10.1093/ofid/ofac635
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author Coghill, Anna E
McGuire, Andrew
Sinha, Sweta
Homad, Leah
Sinha, Irika
Sholukh, Anton
Koh, Woon-Puay
Yuan, Jian Min
author_facet Coghill, Anna E
McGuire, Andrew
Sinha, Sweta
Homad, Leah
Sinha, Irika
Sholukh, Anton
Koh, Woon-Puay
Yuan, Jian Min
author_sort Coghill, Anna E
collection PubMed
description We evaluated antibody against Epstein-Barr virus glycoproteins (gp350, gH/gL, gB, gp42) in 97 nasopharyngeal carcinoma (NPC) cases and 97 cancer-free controls. Each unit increase in log-transformed antibody against gp350 and gH/gL was associated with 2.27 (95% confidence interval [CI], 1.20–4.29) and 2.18 (95% CI, 1.22–3.90) higher odds of NPC, respectively. This association was more apparent for NPC diagnosed within 5 years of antibody measurement.
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spelling pubmed-97457752022-12-13 Epstein-Barr Virus Glycoprotein Antibody Titers and Risk of Nasopharyngeal Carcinoma Coghill, Anna E McGuire, Andrew Sinha, Sweta Homad, Leah Sinha, Irika Sholukh, Anton Koh, Woon-Puay Yuan, Jian Min Open Forum Infect Dis Brief Report We evaluated antibody against Epstein-Barr virus glycoproteins (gp350, gH/gL, gB, gp42) in 97 nasopharyngeal carcinoma (NPC) cases and 97 cancer-free controls. Each unit increase in log-transformed antibody against gp350 and gH/gL was associated with 2.27 (95% confidence interval [CI], 1.20–4.29) and 2.18 (95% CI, 1.22–3.90) higher odds of NPC, respectively. This association was more apparent for NPC diagnosed within 5 years of antibody measurement. Oxford University Press 2022-11-25 /pmc/articles/PMC9745775/ /pubmed/36519117 http://dx.doi.org/10.1093/ofid/ofac635 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Coghill, Anna E
McGuire, Andrew
Sinha, Sweta
Homad, Leah
Sinha, Irika
Sholukh, Anton
Koh, Woon-Puay
Yuan, Jian Min
Epstein-Barr Virus Glycoprotein Antibody Titers and Risk of Nasopharyngeal Carcinoma
title Epstein-Barr Virus Glycoprotein Antibody Titers and Risk of Nasopharyngeal Carcinoma
title_full Epstein-Barr Virus Glycoprotein Antibody Titers and Risk of Nasopharyngeal Carcinoma
title_fullStr Epstein-Barr Virus Glycoprotein Antibody Titers and Risk of Nasopharyngeal Carcinoma
title_full_unstemmed Epstein-Barr Virus Glycoprotein Antibody Titers and Risk of Nasopharyngeal Carcinoma
title_short Epstein-Barr Virus Glycoprotein Antibody Titers and Risk of Nasopharyngeal Carcinoma
title_sort epstein-barr virus glycoprotein antibody titers and risk of nasopharyngeal carcinoma
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9745775/
https://www.ncbi.nlm.nih.gov/pubmed/36519117
http://dx.doi.org/10.1093/ofid/ofac635
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