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Experimental and In Silico Analysis of TEM β-Lactamase Adaptive Evolution

[Image: see text] Multiple mutations often have non-additive (epistatic) phenotypic effects. Epistasis is of fundamental biological relevance but is not well understood mechanistically. Adaptive evolution, i.e., the evolution of new biochemical activities, is rich in epistatic interactions. To bette...

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Detalles Bibliográficos
Autores principales:	Standley, Melissa, Blay, Vincent, Beleva Guthrie, Violeta, Kim, Jay, Lyman, Audrey, Moya, Andrés, Karchin, Rachel, Camps, Manel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9745794/ https://www.ncbi.nlm.nih.gov/pubmed/36377311 http://dx.doi.org/10.1021/acsinfecdis.2c00216

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