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Combining superselective catheterization and electrochemotherapy: A new technological approach to the treatment of high-flow head and neck vascular malformations

INTRODUCTION: The study aims to demonstrate a combination of superselective catheterization and electrochemotherapy as a feasible and effective new technological approach in treating high-flow vascular malformations of the head and neck region. PATIENTS AND METHODS: In the patient with high-flow art...

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Autores principales: Krt, Aljosa, Cemazar, Maja, Lovric, Dimitrij, Sersa, Gregor, Jamsek, Crt, Groselj, Ales
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9745808/
https://www.ncbi.nlm.nih.gov/pubmed/36523962
http://dx.doi.org/10.3389/fonc.2022.1025270
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author Krt, Aljosa
Cemazar, Maja
Lovric, Dimitrij
Sersa, Gregor
Jamsek, Crt
Groselj, Ales
author_facet Krt, Aljosa
Cemazar, Maja
Lovric, Dimitrij
Sersa, Gregor
Jamsek, Crt
Groselj, Ales
author_sort Krt, Aljosa
collection PubMed
description INTRODUCTION: The study aims to demonstrate a combination of superselective catheterization and electrochemotherapy as a feasible and effective new technological approach in treating high-flow vascular malformations of the head and neck region. PATIENTS AND METHODS: In the patient with high-flow arteriovenous malformation of the lower lip, superselective catheterization was performed under general anesthesia. The microcatheter was used to administer 750 IU BLM intra-arterially into the feeding vessel. The whole malformation surface was then covered with 15 applications of electric pulses using the plate electrode. RESULTS: Excellent response, without functional or aesthetic deficits, was obtained in 10 weeks. During this period, debridement and necrectomy were performed regularly on follow-up visits. The pain was managed with oral paracetamol and sodium metamizole. CONCLUSION: Combining electrochemotherapy using bleomycin with superselective catheterization and arteriography is a feasible treatment option for high-flow vascular malformations in the head and neck region and could play a significant role in managing these challenging lesions.
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spelling pubmed-97458082022-12-14 Combining superselective catheterization and electrochemotherapy: A new technological approach to the treatment of high-flow head and neck vascular malformations Krt, Aljosa Cemazar, Maja Lovric, Dimitrij Sersa, Gregor Jamsek, Crt Groselj, Ales Front Oncol Oncology INTRODUCTION: The study aims to demonstrate a combination of superselective catheterization and electrochemotherapy as a feasible and effective new technological approach in treating high-flow vascular malformations of the head and neck region. PATIENTS AND METHODS: In the patient with high-flow arteriovenous malformation of the lower lip, superselective catheterization was performed under general anesthesia. The microcatheter was used to administer 750 IU BLM intra-arterially into the feeding vessel. The whole malformation surface was then covered with 15 applications of electric pulses using the plate electrode. RESULTS: Excellent response, without functional or aesthetic deficits, was obtained in 10 weeks. During this period, debridement and necrectomy were performed regularly on follow-up visits. The pain was managed with oral paracetamol and sodium metamizole. CONCLUSION: Combining electrochemotherapy using bleomycin with superselective catheterization and arteriography is a feasible treatment option for high-flow vascular malformations in the head and neck region and could play a significant role in managing these challenging lesions. Frontiers Media S.A. 2022-11-29 /pmc/articles/PMC9745808/ /pubmed/36523962 http://dx.doi.org/10.3389/fonc.2022.1025270 Text en Copyright © 2022 Krt, Cemazar, Lovric, Sersa, Jamsek and Groselj https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Krt, Aljosa
Cemazar, Maja
Lovric, Dimitrij
Sersa, Gregor
Jamsek, Crt
Groselj, Ales
Combining superselective catheterization and electrochemotherapy: A new technological approach to the treatment of high-flow head and neck vascular malformations
title Combining superselective catheterization and electrochemotherapy: A new technological approach to the treatment of high-flow head and neck vascular malformations
title_full Combining superselective catheterization and electrochemotherapy: A new technological approach to the treatment of high-flow head and neck vascular malformations
title_fullStr Combining superselective catheterization and electrochemotherapy: A new technological approach to the treatment of high-flow head and neck vascular malformations
title_full_unstemmed Combining superselective catheterization and electrochemotherapy: A new technological approach to the treatment of high-flow head and neck vascular malformations
title_short Combining superselective catheterization and electrochemotherapy: A new technological approach to the treatment of high-flow head and neck vascular malformations
title_sort combining superselective catheterization and electrochemotherapy: a new technological approach to the treatment of high-flow head and neck vascular malformations
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9745808/
https://www.ncbi.nlm.nih.gov/pubmed/36523962
http://dx.doi.org/10.3389/fonc.2022.1025270
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