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Working memory assessment using cambridge neuropsychological test automated battery can help in the diagnosis of mild cognitive impairment: a systematic review and meta-analysis
Mild cognitive impairment (MCI) is an interstitial state between normal aging and dementia. OBJECTIVE: In this study, we investigated working memory (WM) profiles of MCI patients using the Cambridge Neuropsychological Test Automated Battery (CANTAB). We also examined the diagnostic accuracy and poss...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9745972/ https://www.ncbi.nlm.nih.gov/pubmed/36530766 http://dx.doi.org/10.1590/1980-5764-dn-2022-0006 |
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author | Sabahi, Zahra Farhoudi, Mehdi Naseri, Amirreza Talebi, Mahnaz |
author_facet | Sabahi, Zahra Farhoudi, Mehdi Naseri, Amirreza Talebi, Mahnaz |
author_sort | Sabahi, Zahra |
collection | PubMed |
description | Mild cognitive impairment (MCI) is an interstitial state between normal aging and dementia. OBJECTIVE: In this study, we investigated working memory (WM) profiles of MCI patients using the Cambridge Neuropsychological Test Automated Battery (CANTAB). We also examined the diagnostic accuracy and possible associated factors as secondary outcomes of the study. METHODS: We conducted an electronic search on EMBASE, PubMed, and ScienceDirect databases. Studies with MCI participants and using CANTAB battery subtests for the assessment of WM were included. Meta-analysis was conducted using the CMA2 software. RESULTS: Out of 1537 records, 14 studies were covered in this systematic review, and 7 of them were included in the meta-analysis. There was a significant difference between MCI patients and healthy controls in spatial working memory (SWM) (SDM: 0.535; 95%CI 11–96; p-value=0.014), spatial span (SSP) (SDM: 0.649 95%CI 0.297–0.100; p-value<0.01), and rapid visual information processing (RVP) (SDM: 0.52; 95%CI 0.386–0.654; p-value<0.01). WM function of MCI patients was associated with the cerebrospinal fluid (CSF) levels of tau-protein and amyloid-beta (Aβ). CONCLUSIONS: WM is an impaired cognitive domain in MCI. CANTAB WM subtests including SSP, SWM, and RVP are accurate enough to be used as a proper assessment tool for the diagnosis of MCI in clinical settings. Tau-protein and Aβ are associated with lower WM scores in MCI patients; however, sex, age, psychiatric disorders, apolipoprotein 4 allele, and functional activity scores cannot affect WM. |
format | Online Article Text |
id | pubmed-9745972 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento |
record_format | MEDLINE/PubMed |
spelling | pubmed-97459722022-12-15 Working memory assessment using cambridge neuropsychological test automated battery can help in the diagnosis of mild cognitive impairment: a systematic review and meta-analysis Sabahi, Zahra Farhoudi, Mehdi Naseri, Amirreza Talebi, Mahnaz Dement Neuropsychol Views & Reviews Mild cognitive impairment (MCI) is an interstitial state between normal aging and dementia. OBJECTIVE: In this study, we investigated working memory (WM) profiles of MCI patients using the Cambridge Neuropsychological Test Automated Battery (CANTAB). We also examined the diagnostic accuracy and possible associated factors as secondary outcomes of the study. METHODS: We conducted an electronic search on EMBASE, PubMed, and ScienceDirect databases. Studies with MCI participants and using CANTAB battery subtests for the assessment of WM were included. Meta-analysis was conducted using the CMA2 software. RESULTS: Out of 1537 records, 14 studies were covered in this systematic review, and 7 of them were included in the meta-analysis. There was a significant difference between MCI patients and healthy controls in spatial working memory (SWM) (SDM: 0.535; 95%CI 11–96; p-value=0.014), spatial span (SSP) (SDM: 0.649 95%CI 0.297–0.100; p-value<0.01), and rapid visual information processing (RVP) (SDM: 0.52; 95%CI 0.386–0.654; p-value<0.01). WM function of MCI patients was associated with the cerebrospinal fluid (CSF) levels of tau-protein and amyloid-beta (Aβ). CONCLUSIONS: WM is an impaired cognitive domain in MCI. CANTAB WM subtests including SSP, SWM, and RVP are accurate enough to be used as a proper assessment tool for the diagnosis of MCI in clinical settings. Tau-protein and Aβ are associated with lower WM scores in MCI patients; however, sex, age, psychiatric disorders, apolipoprotein 4 allele, and functional activity scores cannot affect WM. Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento 2022-09-26 /pmc/articles/PMC9745972/ /pubmed/36530766 http://dx.doi.org/10.1590/1980-5764-dn-2022-0006 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License |
spellingShingle | Views & Reviews Sabahi, Zahra Farhoudi, Mehdi Naseri, Amirreza Talebi, Mahnaz Working memory assessment using cambridge neuropsychological test automated battery can help in the diagnosis of mild cognitive impairment: a systematic review and meta-analysis |
title | Working memory assessment using cambridge neuropsychological test automated battery can help in the diagnosis of mild cognitive impairment: a systematic review and meta-analysis |
title_full | Working memory assessment using cambridge neuropsychological test automated battery can help in the diagnosis of mild cognitive impairment: a systematic review and meta-analysis |
title_fullStr | Working memory assessment using cambridge neuropsychological test automated battery can help in the diagnosis of mild cognitive impairment: a systematic review and meta-analysis |
title_full_unstemmed | Working memory assessment using cambridge neuropsychological test automated battery can help in the diagnosis of mild cognitive impairment: a systematic review and meta-analysis |
title_short | Working memory assessment using cambridge neuropsychological test automated battery can help in the diagnosis of mild cognitive impairment: a systematic review and meta-analysis |
title_sort | working memory assessment using cambridge neuropsychological test automated battery can help in the diagnosis of mild cognitive impairment: a systematic review and meta-analysis |
topic | Views & Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9745972/ https://www.ncbi.nlm.nih.gov/pubmed/36530766 http://dx.doi.org/10.1590/1980-5764-dn-2022-0006 |
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