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hUCMSCs carrying exenatide prevent T1DM by improving intestinal microflora composition and islet tissue damage repair

BACKGROUND: Exenatide is a stable analogue of glucagon-like peptide 1 that can reduce postprandial hyperglycemia and has been utilized as adjunctive therapy for type 1 diabetes mellitus (T1DM). The human umbilical cord is a rich source of MSCs, and human umbilical cord mesenchymal stem cells (hUCMSC...

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Detalles Bibliográficos
Autores principales: Wang, Wei, Wang, Yahao, Chi, Jingwei, Tan, Xiaojun, Hu, Jianxia, Ma, Xiaolong, Sun, Xiaofang, Che, Kui, Lv, Wenshan, Wang, Yangang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9746121/
https://www.ncbi.nlm.nih.gov/pubmed/36514009
http://dx.doi.org/10.1186/s10020-022-00526-0