Cargando…

hUCMSCs carrying exenatide prevent T1DM by improving intestinal microflora composition and islet tissue damage repair

BACKGROUND: Exenatide is a stable analogue of glucagon-like peptide 1 that can reduce postprandial hyperglycemia and has been utilized as adjunctive therapy for type 1 diabetes mellitus (T1DM). The human umbilical cord is a rich source of MSCs, and human umbilical cord mesenchymal stem cells (hUCMSC...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Wei, Wang, Yahao, Chi, Jingwei, Tan, Xiaojun, Hu, Jianxia, Ma, Xiaolong, Sun, Xiaofang, Che, Kui, Lv, Wenshan, Wang, Yangang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9746121/ https://www.ncbi.nlm.nih.gov/pubmed/36514009 http://dx.doi.org/10.1186/s10020-022-00526-0

Ejemplares similares

High Induction of IL-6 Secretion From hUCMSCs Optimize the Potential of hUCMSCs and TCZ as Therapy for COVID-19-Related ARDS
por: Lo, Huei-Yu, et al.
Publicado: (2021)

Pyroptosis of MCF7 Cells Induced by the Secreted Factors of hUCMSCs
por: Jiao, Yang, et al.
Publicado: (2018)

hUCMSCs Mitigate LPS-Induced Trained Immunity in Ischemic Stroke
por: Feng, Yi-wei, et al.
Publicado: (2020)

hUCMSC-extracellular vesicles downregulated hepatic stellate cell activation and reduced liver injury in S. japonicum-infected mice
por: Dong, Liyang, et al.
Publicado: (2020)

The Role of Caspase-4 and NLRP1 in MCF7 Cell Pyroptosis Induced by hUCMSC-Secreted Factors
por: Jiao, Yang, et al.
Publicado: (2020)

CGF Membrane Promotes Periodontal Tissue Regeneration Mediated by hUCMSCs through Upregulating TAZ and Osteogenic Differentiation Genes
por: Li, Wenjing, et al.
Publicado: (2021)

Hypoxic hUCMSC-derived extracellular vesicles attenuate allergic airway inflammation and airway remodeling in chronic asthma mice
por: Dong, Liyang, et al.
Publicado: (2021)

Engineering of pre-vascularized urethral patch with muscle flaps and hypoxia-activated hUCMSCs improves its therapeutic outcome
por: Sun, Dongchong, et al.
Publicado: (2014)

A non-invasive strategy for suppressing asthmatic airway inflammation and remodeling: Inhalation of nebulized hypoxic hUCMSC-derived extracellular vesicles
por: Xu, Xiaowei, et al.
Publicado: (2023)

Anti-tumor Effects of IL-1β Induced TRAIL-Expressing hUCMSCs on Embelin Treated Breast Cancer Cell Lines
por: Teng, Jui-Wen, et al.
Publicado: (2023)

A simple and efficient strategy for cell‐based and cell‐free‐based therapies in acute liver failure: hUCMSCs bioartificial liver
por: Feng, Lei, et al.
Publicado: (2023)

miR-146a-5p-modified hUCMSC-derived exosomes facilitate spinal cord function recovery by targeting neurotoxic astrocytes
por: Lai, Xunwei, et al.
Publicado: (2022)

A novel method to improve the osteogenesis capacity of hUCMSCs with dual‐directional pre‐induction under screened co‐culture conditions
por: Rong, Qiong, et al.
Publicado: (2019)

PPARγ-dependent hepatic macrophage switching acts as a central hub for hUCMSC-mediated alleviation of decompensated liver cirrhosis in rats
por: Yao, Yunqi, et al.
Publicado: (2023)

IFN-γ-Primed hUCMSCs Significantly Reduced Inflammation via the Foxp3/ROR-γt/STAT3 Signaling Pathway in an Animal Model of Multiple Sclerosis
por: Ling, Xiao, et al.
Publicado: (2022)

Side population cells derived from hUCMSCs and hPMSCs could inhibit the malignant behaviors of Tn(+) colorectal cancer cells from modifying their O-glycosylation status
por: Hu, Wen, et al.
Publicado: (2023)

Human umbilical cord mesenchymal stromal cells promote the regeneration of severe endometrial damage in a rat model: hUCMSCs promote the recovery of severe endometrial damage
por: Zhuang, Mei, et al.
Publicado: (2021)

Transfer of lncRNA UCA1 by hUCMSCs-derived exosomes protects against hypoxia/reoxygenation injury through impairing miR-143-targeted degradation of Bcl-2
por: Diao, Liwei, et al.
Publicado: (2021)

hUCMSCs reduce theca interstitial cells apoptosis and restore ovarian function in premature ovarian insufficiency rats through regulating NR4A1-mediated mitochondrial mechanisms
por: Luo, Qianqian, et al.
Publicado: (2022)

IL-21-secreting hUCMSCs combined with miR-200c inhibit tumor growth and metastasis via repression of Wnt/β-catenin signaling and epithelial–mesenchymal transition in epithelial ovarian cancer
por: Zhang, Yunxia, et al.
Publicado: (2018)

Effectiveness of Secretome from Human Umbilical Cord Mesenchymal Stem Cells in Gel (10% SM-hUCMSC Gel) for Chronic Wounds (Diabetic and Trophic Ulcer) – Phase 2 Clinical Trial
por: Tan, Sukmawati Tansil, et al.
Publicado: (2023)

HucMSC‐exosomes carrying miR‐326 inhibit neddylation to relieve inflammatory bowel disease in mice
por: Wang, Gaoying, et al.
Publicado: (2020)

SPK1-transfected UCMSC has better therapeutic activity than UCMSC in the treatment of experimental autoimmune encephalomyelitis model of Multiple sclerosis
por: Wang, Yun-Liang, et al.
Publicado: (2018)

Effects of exenatide on urinary albumin in overweight/obese patients with T2DM: a randomized clinical trial
por: Kang, Chao, et al.
Publicado: (2021)

A Response to Article “Effectiveness of Secretome from Human Umbilical Cord Mesenchymal Stem Cells in Gel (10% SM-hUCMSC Gel) for Chronic Wounds (Diabetic and Trophic Ulcer) – Phase 2 Clinical Trial” [Letter]
por: Dwicantika, Annisa, et al.
Publicado: (2023)

The combined effect of mesenchymal stem cells and resveratrol on type 1 diabetic neuropathy
por: Wang, Chen, et al.
Publicado: (2019)

Serum progesterone and retinopathy in male patients with type 2 diabetes: A cross‐sectional study
por: Sun, Shengnan, et al.
Publicado: (2020)

HOXA10 Expressing UCMSCs Transplantation Improved Endometrial Receptivity on Endometrial Injury
por: Wu, Meixian, et al.
Publicado: (2023)

Accelerated Ovarian Aging Among Type 2 Diabetes Patients and Its Association With Adverse Lipid Profile
por: Wang, Yahao, et al.
Publicado: (2022)

Comparison of Glycemic Variability in Chinese T2DM Patients Treated with Exenatide or Insulin Glargine: A Randomized Controlled Trial
por: Yin, Ting-Ting, et al.
Publicado: (2018)

Effects of UCMSCs Delivered through Different Transplantation Approaches on Acute Radiation Enteritis in Rats
por: Li, Jun, et al.
Publicado: (2021)

Endoplasmic reticulum stress in the adipose tissue and monocyte chemoattractant protein‐1 are involved in tacrolimus‐induced diabetes mellitus
por: Sun, Xiaoxia, et al.
Publicado: (2023)

Effects of exenatide versus insulin glargine on body composition in overweight and obese T2DM patients: a randomized controlled trial
por: Yin, Ting-Ting, et al.
Publicado: (2018)

Exenatide Pretreatment Improved Graft Function in Nonhuman Primate Islet Recipients Compared to Treatment after Transplant Only
por: Buss, Jill L., et al.
Publicado: (2012)

Impaired glucose tolerance is associated with enhanced postprandial pancreatic polypeptide secretion
por: Zhao, Yanyun, et al.
Publicado: (2022)

Pancreatitis Incidence in the Exenatide BID, Exenatide QW, and Exenatide QW Suspension Development Programs: Pooled Analysis of 35 Clinical Trials
por: Vetter, Marion L., et al.
Publicado: (2019)

Comparison of effects of HucMSCs, exosomes, and conditioned medium on NASH
por: Liang, Chenchen, et al.
Publicado: (2023)

Obesity is associated with impaired postprandial pancreatic polypeptide secretion
por: Zhao, Yanyun, et al.
Publicado: (2023)

Effects and mechanisms of mUCMSCs on ovarian structure and function in naturally ageing C57 mice
por: Pan, Xing-Hua, et al.
Publicado: (2021)

Pre-incubation with hucMSC-exosomes prevents cisplatin-induced nephrotoxicity by activating autophagy
por: Wang, Bingying, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_sjkvt9jg4h2bp0dai265mt2bao