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Drugs for neglected tropical diseases: availability of age-appropriate oral formulations for young children

It is recognised that paediatric indications and age-appropriate formulations are required to ensure that paediatric populations receive appropriate pharmacotherapeutic treatment. The lack of information on dosing, efficacy and safety data (labelling) is a well-recognised problem for all diseases af...

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Autores principales: Al-Obaidi, Issraa, Krome, Anna K., Wagner, Karl G., Pfarr, Kenneth, Kuesel, Annette C., Batchelor, Hannah K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9746163/
https://www.ncbi.nlm.nih.gov/pubmed/36510275
http://dx.doi.org/10.1186/s13071-022-05546-7
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author Al-Obaidi, Issraa
Krome, Anna K.
Wagner, Karl G.
Pfarr, Kenneth
Kuesel, Annette C.
Batchelor, Hannah K.
author_facet Al-Obaidi, Issraa
Krome, Anna K.
Wagner, Karl G.
Pfarr, Kenneth
Kuesel, Annette C.
Batchelor, Hannah K.
author_sort Al-Obaidi, Issraa
collection PubMed
description It is recognised that paediatric indications and age-appropriate formulations are required to ensure that paediatric populations receive appropriate pharmacotherapeutic treatment. The lack of information on dosing, efficacy and safety data (labelling) is a well-recognised problem for all diseases affecting children. For neglected tropical diseases, the fact that they affect to a large extent poor and marginalised populations in low- and middle-income countries means that there is a low economic return on investment into paediatric development activities compared to other diseases [e.g. human immunodeficiency virus (HIV)]. This review provides an introduction to issues affecting the availability and development of paediatric population-relevant data and appropriate formulations of drugs for NTDs. We are summarising why age-appropriate formulations are important to ensure treatment efficacy, safety and effectiveness, outline initiatives to increase the number of paediatric indications/labelling and age-appropriate formulations, provide an overview of publicly available information on the formulations of oral drugs for NTDs relative to age appropriateness and give an introduction to options for age-appropriate formulations. The review completes with ‘case studies’ of recently developed paediatric formulations for NTDs, complemented by case studies for fixed-dose combinations for HIV infection in children since such formulations have not been developed for NTDs. GRAPHICAL ABSTRACT: [Image: see text]
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spelling pubmed-97461632022-12-14 Drugs for neglected tropical diseases: availability of age-appropriate oral formulations for young children Al-Obaidi, Issraa Krome, Anna K. Wagner, Karl G. Pfarr, Kenneth Kuesel, Annette C. Batchelor, Hannah K. Parasit Vectors Review It is recognised that paediatric indications and age-appropriate formulations are required to ensure that paediatric populations receive appropriate pharmacotherapeutic treatment. The lack of information on dosing, efficacy and safety data (labelling) is a well-recognised problem for all diseases affecting children. For neglected tropical diseases, the fact that they affect to a large extent poor and marginalised populations in low- and middle-income countries means that there is a low economic return on investment into paediatric development activities compared to other diseases [e.g. human immunodeficiency virus (HIV)]. This review provides an introduction to issues affecting the availability and development of paediatric population-relevant data and appropriate formulations of drugs for NTDs. We are summarising why age-appropriate formulations are important to ensure treatment efficacy, safety and effectiveness, outline initiatives to increase the number of paediatric indications/labelling and age-appropriate formulations, provide an overview of publicly available information on the formulations of oral drugs for NTDs relative to age appropriateness and give an introduction to options for age-appropriate formulations. The review completes with ‘case studies’ of recently developed paediatric formulations for NTDs, complemented by case studies for fixed-dose combinations for HIV infection in children since such formulations have not been developed for NTDs. GRAPHICAL ABSTRACT: [Image: see text] BioMed Central 2022-12-12 /pmc/articles/PMC9746163/ /pubmed/36510275 http://dx.doi.org/10.1186/s13071-022-05546-7 Text en © World Health Organization 2022 https://creativecommons.org/licenses/by/3.0/Open Access This is an Open Access article published under the CC BY 3.0 IGO license which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In any use of this article, there should be no suggestion that WHO endorses any specific organization, products, or services. The use of the WHO logo is not permitted. This notice should be preserved along with the article’s original URL.
spellingShingle Review
Al-Obaidi, Issraa
Krome, Anna K.
Wagner, Karl G.
Pfarr, Kenneth
Kuesel, Annette C.
Batchelor, Hannah K.
Drugs for neglected tropical diseases: availability of age-appropriate oral formulations for young children
title Drugs for neglected tropical diseases: availability of age-appropriate oral formulations for young children
title_full Drugs for neglected tropical diseases: availability of age-appropriate oral formulations for young children
title_fullStr Drugs for neglected tropical diseases: availability of age-appropriate oral formulations for young children
title_full_unstemmed Drugs for neglected tropical diseases: availability of age-appropriate oral formulations for young children
title_short Drugs for neglected tropical diseases: availability of age-appropriate oral formulations for young children
title_sort drugs for neglected tropical diseases: availability of age-appropriate oral formulations for young children
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9746163/
https://www.ncbi.nlm.nih.gov/pubmed/36510275
http://dx.doi.org/10.1186/s13071-022-05546-7
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