The employment of vaccinia virus for colorectal cancer treatment: A review of preclinical and clinical studies

Colorectal cancer (CRC) is one of the leading malignancies that causes death worldwide. Cancer vaccines and oncolytic immunotherapy bring new hope for patients with advanced CRC. The capability of vaccinia virus (VV) in carrying foreign genes as antigens or immunostimulatory factors has been demonst...

Descripción completa

Detalles Bibliográficos
Autores principales: Ling, Qiaoyun, Zheng, Bichun, Chen, Xudong, Ye, Shaoshun, Cheng, Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Immunotherapeutics – Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9746450/
https://www.ncbi.nlm.nih.gov/pubmed/36369829
http://dx.doi.org/10.1080/21645515.2022.2143698
_version_ 1784849362632835072
author Ling, Qiaoyun
Zheng, Bichun
Chen, Xudong
Ye, Shaoshun
Cheng, Quan
author_facet Ling, Qiaoyun
Zheng, Bichun
Chen, Xudong
Ye, Shaoshun
Cheng, Quan
author_sort Ling, Qiaoyun
collection PubMed
description Colorectal cancer (CRC) is one of the leading malignancies that causes death worldwide. Cancer vaccines and oncolytic immunotherapy bring new hope for patients with advanced CRC. The capability of vaccinia virus (VV) in carrying foreign genes as antigens or immunostimulatory factors has been demonstrated in animal models. VV of Wyeth, Western Reserve, Lister, Tian Tan, and Copenhagen strains have been engineered for the induction of antitumor response in multiple cancers. This paper summarized the preclinical and clinical application and development of VV serving as cancer vaccines and oncolytic vectors in CRC treatment. Additionally, the remaining challenges and future direction are also discussed.
format Online
Article
Text
id pubmed-9746450
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-97464502022-12-14 The employment of vaccinia virus for colorectal cancer treatment: A review of preclinical and clinical studies Ling, Qiaoyun Zheng, Bichun Chen, Xudong Ye, Shaoshun Cheng, Quan Hum Vaccin Immunother Immunotherapeutics – Review Colorectal cancer (CRC) is one of the leading malignancies that causes death worldwide. Cancer vaccines and oncolytic immunotherapy bring new hope for patients with advanced CRC. The capability of vaccinia virus (VV) in carrying foreign genes as antigens or immunostimulatory factors has been demonstrated in animal models. VV of Wyeth, Western Reserve, Lister, Tian Tan, and Copenhagen strains have been engineered for the induction of antitumor response in multiple cancers. This paper summarized the preclinical and clinical application and development of VV serving as cancer vaccines and oncolytic vectors in CRC treatment. Additionally, the remaining challenges and future direction are also discussed. Taylor & Francis 2022-11-11 /pmc/articles/PMC9746450/ /pubmed/36369829 http://dx.doi.org/10.1080/21645515.2022.2143698 Text en © 2022 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Immunotherapeutics – Review
Ling, Qiaoyun
Zheng, Bichun
Chen, Xudong
Ye, Shaoshun
Cheng, Quan
The employment of vaccinia virus for colorectal cancer treatment: A review of preclinical and clinical studies
title The employment of vaccinia virus for colorectal cancer treatment: A review of preclinical and clinical studies
title_full The employment of vaccinia virus for colorectal cancer treatment: A review of preclinical and clinical studies
title_fullStr The employment of vaccinia virus for colorectal cancer treatment: A review of preclinical and clinical studies
title_full_unstemmed The employment of vaccinia virus for colorectal cancer treatment: A review of preclinical and clinical studies
title_short The employment of vaccinia virus for colorectal cancer treatment: A review of preclinical and clinical studies
title_sort employment of vaccinia virus for colorectal cancer treatment: a review of preclinical and clinical studies
topic Immunotherapeutics – Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9746450/
https://www.ncbi.nlm.nih.gov/pubmed/36369829
http://dx.doi.org/10.1080/21645515.2022.2143698
work_keys_str_mv AT lingqiaoyun theemploymentofvacciniavirusforcolorectalcancertreatmentareviewofpreclinicalandclinicalstudies
AT zhengbichun theemploymentofvacciniavirusforcolorectalcancertreatmentareviewofpreclinicalandclinicalstudies
AT chenxudong theemploymentofvacciniavirusforcolorectalcancertreatmentareviewofpreclinicalandclinicalstudies
AT yeshaoshun theemploymentofvacciniavirusforcolorectalcancertreatmentareviewofpreclinicalandclinicalstudies
AT chengquan theemploymentofvacciniavirusforcolorectalcancertreatmentareviewofpreclinicalandclinicalstudies
AT lingqiaoyun employmentofvacciniavirusforcolorectalcancertreatmentareviewofpreclinicalandclinicalstudies
AT zhengbichun employmentofvacciniavirusforcolorectalcancertreatmentareviewofpreclinicalandclinicalstudies
AT chenxudong employmentofvacciniavirusforcolorectalcancertreatmentareviewofpreclinicalandclinicalstudies
AT yeshaoshun employmentofvacciniavirusforcolorectalcancertreatmentareviewofpreclinicalandclinicalstudies
AT chengquan employmentofvacciniavirusforcolorectalcancertreatmentareviewofpreclinicalandclinicalstudies

Ejemplares similares