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A systematic and thematic analysis of the top 100 cited articles on mRNA vaccine indexed in Scopus database

The success of mRNA vaccines against SARS-CoV-2 implies that this technology can be applied to target any pathogen. However, the scientific production and research trends using the bibliometric method are still unknown. The top 100 most cited articles on mRNA vaccine research were obtained from the...

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Autores principales: Musa, Hassan H., Musa, Taha H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9746518/
https://www.ncbi.nlm.nih.gov/pubmed/36328513
http://dx.doi.org/10.1080/21645515.2022.2135927
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author Musa, Hassan H.
Musa, Taha H.
author_facet Musa, Hassan H.
Musa, Taha H.
author_sort Musa, Hassan H.
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description The success of mRNA vaccines against SARS-CoV-2 implies that this technology can be applied to target any pathogen. However, the scientific production and research trends using the bibliometric method are still unknown. The top 100 most cited articles on mRNA vaccine research were obtained from the Scopus database from 1995 to 2021. Bibliometrix, an R-Package, and VOSviewer 1.6.11 were used for data analysis. There is a rapid growth in scientific outputs with a gradual increase in 2021. The United States produced 45 (45%) of the articles, followed by Germany with 15 (15%) and Israel with 10 (10%). The New England Journal of Medicine published the most papers in this field 13 (13%), followed by Nature 6(6%). Barney S. Graham was the most productive author among the top 100 most cited mRNA vaccine articles. University of Pennsylvania Perelman School of Medicine, US, was the top ranking institution, having 37 (37%). The visualization map clearly and spontaneously displayed the current state and research hot spots of mRNA research from a specific perspective. The most frequent keywords were COVID-19, vaccine, mRNA vaccine, mRNA, SARS-CoV-2, and immunogenicity, among others. A systematic review of the articles provided evidence that out of 100 articles, approximately 25 (25%) were focused on vaccine production and evaluation, followed by 26 (26%) in mRNA vaccine safety and efficacy, 23 (23%) were into mRNA vaccination, 23 (23%) considered risk factors associated with mRNA vaccination, while 8 (8%) of the articles covered the issue of mRNA vaccine delivery. In addition, 42% of the articles focused on COVID-19, 17% on cancer, 8% on influenza virus, 4% on COVID-19 and kidney disease, 3% COVID-19 and myocarditis, and 3% on rabies virus, among others. The findings of this systematic and thematic analysis provided the knowledge basis for further research on mRNA vaccines globally.
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spelling pubmed-97465182022-12-14 A systematic and thematic analysis of the top 100 cited articles on mRNA vaccine indexed in Scopus database Musa, Hassan H. Musa, Taha H. Hum Vaccin Immunother Technology – Research Article The success of mRNA vaccines against SARS-CoV-2 implies that this technology can be applied to target any pathogen. However, the scientific production and research trends using the bibliometric method are still unknown. The top 100 most cited articles on mRNA vaccine research were obtained from the Scopus database from 1995 to 2021. Bibliometrix, an R-Package, and VOSviewer 1.6.11 were used for data analysis. There is a rapid growth in scientific outputs with a gradual increase in 2021. The United States produced 45 (45%) of the articles, followed by Germany with 15 (15%) and Israel with 10 (10%). The New England Journal of Medicine published the most papers in this field 13 (13%), followed by Nature 6(6%). Barney S. Graham was the most productive author among the top 100 most cited mRNA vaccine articles. University of Pennsylvania Perelman School of Medicine, US, was the top ranking institution, having 37 (37%). The visualization map clearly and spontaneously displayed the current state and research hot spots of mRNA research from a specific perspective. The most frequent keywords were COVID-19, vaccine, mRNA vaccine, mRNA, SARS-CoV-2, and immunogenicity, among others. A systematic review of the articles provided evidence that out of 100 articles, approximately 25 (25%) were focused on vaccine production and evaluation, followed by 26 (26%) in mRNA vaccine safety and efficacy, 23 (23%) were into mRNA vaccination, 23 (23%) considered risk factors associated with mRNA vaccination, while 8 (8%) of the articles covered the issue of mRNA vaccine delivery. In addition, 42% of the articles focused on COVID-19, 17% on cancer, 8% on influenza virus, 4% on COVID-19 and kidney disease, 3% COVID-19 and myocarditis, and 3% on rabies virus, among others. The findings of this systematic and thematic analysis provided the knowledge basis for further research on mRNA vaccines globally. Taylor & Francis 2022-11-03 /pmc/articles/PMC9746518/ /pubmed/36328513 http://dx.doi.org/10.1080/21645515.2022.2135927 Text en © 2022 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Technology – Research Article
Musa, Hassan H.
Musa, Taha H.
A systematic and thematic analysis of the top 100 cited articles on mRNA vaccine indexed in Scopus database
title A systematic and thematic analysis of the top 100 cited articles on mRNA vaccine indexed in Scopus database
title_full A systematic and thematic analysis of the top 100 cited articles on mRNA vaccine indexed in Scopus database
title_fullStr A systematic and thematic analysis of the top 100 cited articles on mRNA vaccine indexed in Scopus database
title_full_unstemmed A systematic and thematic analysis of the top 100 cited articles on mRNA vaccine indexed in Scopus database
title_short A systematic and thematic analysis of the top 100 cited articles on mRNA vaccine indexed in Scopus database
title_sort systematic and thematic analysis of the top 100 cited articles on mrna vaccine indexed in scopus database
topic Technology – Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9746518/
https://www.ncbi.nlm.nih.gov/pubmed/36328513
http://dx.doi.org/10.1080/21645515.2022.2135927
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