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Dynamized ultra-low dilution of Ruta graveolens disrupts plasma membrane organization and decreases migration of melanoma cancer cell
Cutaneous melanoma is a cancer with a very poor prognosis mainly because of metastatic dissemination and therefore a deregulation of cell migration. Current therapies can benefit from complementary medicines as supportive care in oncology. In our study, we show that a dynamized ultra-low dilution of...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9746621/ https://www.ncbi.nlm.nih.gov/pubmed/36503402 http://dx.doi.org/10.1080/19336918.2022.2154732 |
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author | Fuselier, Camille Dufay, Eleonore Berquand, Alexandre Terryn, Christine Bonnomet, Arnaud Molinari, Michael Martiny, Laurent Schneider, Christophe |
author_facet | Fuselier, Camille Dufay, Eleonore Berquand, Alexandre Terryn, Christine Bonnomet, Arnaud Molinari, Michael Martiny, Laurent Schneider, Christophe |
author_sort | Fuselier, Camille |
collection | PubMed |
description | Cutaneous melanoma is a cancer with a very poor prognosis mainly because of metastatic dissemination and therefore a deregulation of cell migration. Current therapies can benefit from complementary medicines as supportive care in oncology. In our study, we show that a dynamized ultra-low dilution of Ruta Graveolens leads to an in vitro inhibition of migration on fibronectin of B16F10 melanoma cells, as well as a decrease in metastatic dissemination in vivo. These effects appear to be due to a disruption of plasma membrane organization, with a change in cell and membrane stiffness, associated with a disorganization of the actin cytoskeleton and a modification of the lipid composition of the plasma membrane. Together, these results demonstrate, in in vitro and in vivo models of cutaneous melanoma, an anti-cancer and anti-metastatic activity of ultra-low dynamized dilution of Ruta graveolens and reinforce its interest as complementary medicine in oncology. |
format | Online Article Text |
id | pubmed-9746621 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-97466212023-02-06 Dynamized ultra-low dilution of Ruta graveolens disrupts plasma membrane organization and decreases migration of melanoma cancer cell Fuselier, Camille Dufay, Eleonore Berquand, Alexandre Terryn, Christine Bonnomet, Arnaud Molinari, Michael Martiny, Laurent Schneider, Christophe Cell Adh Migr Research Paper Cutaneous melanoma is a cancer with a very poor prognosis mainly because of metastatic dissemination and therefore a deregulation of cell migration. Current therapies can benefit from complementary medicines as supportive care in oncology. In our study, we show that a dynamized ultra-low dilution of Ruta Graveolens leads to an in vitro inhibition of migration on fibronectin of B16F10 melanoma cells, as well as a decrease in metastatic dissemination in vivo. These effects appear to be due to a disruption of plasma membrane organization, with a change in cell and membrane stiffness, associated with a disorganization of the actin cytoskeleton and a modification of the lipid composition of the plasma membrane. Together, these results demonstrate, in in vitro and in vivo models of cutaneous melanoma, an anti-cancer and anti-metastatic activity of ultra-low dynamized dilution of Ruta graveolens and reinforce its interest as complementary medicine in oncology. Taylor & Francis 2022-12-11 /pmc/articles/PMC9746621/ /pubmed/36503402 http://dx.doi.org/10.1080/19336918.2022.2154732 Text en © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Paper Fuselier, Camille Dufay, Eleonore Berquand, Alexandre Terryn, Christine Bonnomet, Arnaud Molinari, Michael Martiny, Laurent Schneider, Christophe Dynamized ultra-low dilution of Ruta graveolens disrupts plasma membrane organization and decreases migration of melanoma cancer cell |
title | Dynamized ultra-low dilution of Ruta graveolens disrupts plasma membrane organization and decreases migration of melanoma cancer cell |
title_full | Dynamized ultra-low dilution of Ruta graveolens disrupts plasma membrane organization and decreases migration of melanoma cancer cell |
title_fullStr | Dynamized ultra-low dilution of Ruta graveolens disrupts plasma membrane organization and decreases migration of melanoma cancer cell |
title_full_unstemmed | Dynamized ultra-low dilution of Ruta graveolens disrupts plasma membrane organization and decreases migration of melanoma cancer cell |
title_short | Dynamized ultra-low dilution of Ruta graveolens disrupts plasma membrane organization and decreases migration of melanoma cancer cell |
title_sort | dynamized ultra-low dilution of ruta graveolens disrupts plasma membrane organization and decreases migration of melanoma cancer cell |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9746621/ https://www.ncbi.nlm.nih.gov/pubmed/36503402 http://dx.doi.org/10.1080/19336918.2022.2154732 |
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