Culture media composition influences patient-derived organoid ability to predict therapeutic responses in gastrointestinal cancers

BACKGROUND: A patient-derived organoid (PDO) platform may serve as a promising tool for translational cancer research. In this study, we evaluated PDO’s ability to predict clinical response to gastrointestinal (GI) cancers. METHODS: We generated PDOs from primary and metastatic lesions of patients w...

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Detalles Bibliográficos
Autores principales: Hogenson, Tara L., Xie, Hao, Phillips, William J., Toruner, Merih D., Li, Jenny J., Horn, Isaac P., Kennedy, Devin J., Almada, Luciana L., Marks, David L., Carr, Ryan M., Toruner, Murat, Sigafoos, Ashley N., Koenig-Kappes, Amanda N., Olson, Rachel L.O., Tolosa, Ezequiel J., Zhang, Cheng, Li, Hu, Doles, Jason D., Bleeker, Jonathan, Barrett, Michael T., Boyum, James H., Kipp, Benjamin R., Mahipal, Amit, Hubbard, Joleen M., Scheffler Hanson, Temperance J., Petersen, Gloria M., Dasari, Surendra, Oberg, Ann L., Truty, Mark J., Graham, Rondell P., Levy, Michael J., Zhu, Mojun, Billadeau, Daniel D., Adjei, Alex A., Dusetti, Nelson, Iovanna, Juan L., Bekaii-Saab, Tanios S., Ma, Wen Wee, Fernandez-Zapico, Martin E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Clinical Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9746806/
https://www.ncbi.nlm.nih.gov/pubmed/36256477
http://dx.doi.org/10.1172/jci.insight.158060

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