The HIF-prolyl hydroxylases have distinct and nonredundant roles in colitis-associated cancer

Colitis-associated colorectal cancer (CAC) is a severe complication of inflammatory bowel disease (IBD). HIF-prolyl hydroxylases (PHD1, PHD2, and PHD3) control cellular adaptation to hypoxia and are considered promising therapeutic targets in IBD. However, their relevance in the pathogenesis of CAC...

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Detalles Bibliográficos
Autores principales: Kennel, Kilian B., Burmeister, Julius, Radhakrishnan, Praveen, Giese, Nathalia A., Giese, Thomas, Salfenmoser, Martin, Gebhardt, Jasper M., Strowitzki, Moritz J., Taylor, Cormac T., Wielockx, Ben, Schneider, Martin, Harnoss, Jonathan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9746807/
https://www.ncbi.nlm.nih.gov/pubmed/36509284
http://dx.doi.org/10.1172/jci.insight.153337

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9746807/
https://www.ncbi.nlm.nih.gov/pubmed/36509284
http://dx.doi.org/10.1172/jci.insight.153337

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