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Neoadjuvant chemotherapy drives intratumoral T cells toward a proinflammatory profile in pancreatic cancer

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis. At diagnosis, only 20% of patients with PDAC are eligible for primary resection. Neoadjuvant chemotherapy can enable surgical resection in 30%–40% of patients with locally advanced and borderline resectable PDAC. The effects...

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Detalles Bibliográficos
Autores principales:	Heiduk, Max, Plesca, Ioana, Glück, Jessica, Müller, Luise, Digomann, David, Reiche, Charlotte, von Renesse, Janusz, Decker, Rahel, Kahlert, Christoph, Sommer, Ulrich, Aust, Daniela E., Schmitz, Marc, Weitz, Jürgen, Seifert, Lena, Seifert, Adrian M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2022
Materias:	Clinical Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9746809/ https://www.ncbi.nlm.nih.gov/pubmed/36509285 http://dx.doi.org/10.1172/jci.insight.152761

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