Single-cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis

Progressive fibrosis and maladaptive organ repair result in significant morbidity and millions of premature deaths annually. Senescent cells accumulate with aging and after injury and are implicated in organ fibrosis, but the mechanisms by which senescence influences repair are poorly understood. Us...

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Detalles Bibliográficos
Autores principales: O’Sullivan, Eoin D., Mylonas, Katie J., Bell, Rachel, Carvalho, Cyril, Baird, David P., Cairns, Carolynn, Gallagher, Kevin M., Campbell, Ross, Docherty, Marie, Laird, Alexander, Henderson, Neil C., Chandra, Tamir, Kirschner, Kristina, Conway, Bryan, Dihazi, Gry H., Zeisberg, Michael, Hughes, Jeremy, Denby, Laura, Dihazi, Hassan, Ferenbach, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9746814/
https://www.ncbi.nlm.nih.gov/pubmed/36509292
http://dx.doi.org/10.1172/jci.insight.154124

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