Consecutive BNT162b2 mRNA vaccination induces short-term epigenetic memory in innate immune cells

Consecutive mRNA vaccinations against SARS-CoV-2 reinforced both innate and adaptive immune responses. However, it remains unclear whether the enhanced innate immune responses are mediated by epigenetic regulation and, if so, whether these effects persist. Using mass cytometry, RNA-Seq, and ATAC-Seq...

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Detalles Bibliográficos
Autores principales: Yamaguchi, Yuta, Kato, Yasuhiro, Edahiro, Ryuya, Søndergaard, Jonas N., Murakami, Teruaki, Amiya, Saori, Nameki, Shinichiro, Yoshimine, Yuko, Morita, Takayoshi, Takeshima, Yusuke, Sakakibara, Shuhei, Naito, Yoko, Motooka, Daisuke, Liu, Yu-Chen, Shirai, Yuya, Okita, Yasutaka, Fujimoto, Jun, Hirata, Haruhiko, Takeda, Yoshito, Wing, James B., Okuzaki, Daisuke, Okada, Yukinori, Kumanogoh, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9746816/
https://www.ncbi.nlm.nih.gov/pubmed/36282593
http://dx.doi.org/10.1172/jci.insight.163347

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