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Targeting TNF-α–producing macrophages activates antitumor immunity in pancreatic cancer via IL-33 signaling

Pancreatic ductal adenocarcinoma (PDA) remains resistant to immune therapies, largely owing to robustly fibrotic and immunosuppressive tumor microenvironments. It has been postulated that excessive accumulation of immunosuppressive myeloid cells influences immunotherapy resistance, and recent studie...

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Detalles Bibliográficos
Autores principales:	Dixit, Ajay, Sarver, Aaron, Zettervall, Jon, Huang, Huocong, Zheng, Kexin, Brekken, Rolf A., Provenzano, Paolo P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9746819/ https://www.ncbi.nlm.nih.gov/pubmed/36256464 http://dx.doi.org/10.1172/jci.insight.153242

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