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Autophagy inducer rapamycin treatment reduces IFN-I–mediated Inflammation and improves anti–HIV-1 T cell response in vivo

A hallmark of HIV-1 infection is chronic inflammation, even in patients treated with antiretroviral therapy (ART). Chronic inflammation drives HIV-1 pathogenesis, leading to loss of CD4(+) T cells and exhaustion of antiviral immunity. Therefore, strategies to safely reduce systematic inflammation ar...

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Detalles Bibliográficos
Autores principales:	Mu, Wenli, Rezek, Valerie, Martin, Heather, Carrillo, Mayra A., Tomer, Shallu, Hamid, Philip, Lizarraga, Miguel A., Tibbe, Tristan D., Yang, Otto O., Jamieson, Beth D., Kitchen, Scott G., Zhen, Anjie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9746825/ https://www.ncbi.nlm.nih.gov/pubmed/36509289 http://dx.doi.org/10.1172/jci.insight.159136

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