GATOR2-dependent mTORC1 activity is a therapeutic vulnerability in FOXO1 fusion–positive rhabdomyosarcoma

Oncogenic FOXO1 gene fusions drive a subset of rhabdomyosarcoma (RMS) with poor survival; to date, these cancer drivers are therapeutically intractable. To identify new therapies for this disease, we undertook an isogenic CRISPR-interference screen to define PAX3-FOXO1–specific genetic dependencies...

Descripción completa

Detalles Bibliográficos
Autores principales: Morales, Jacqueline, Allegakoen, David V., Garcia, José A., Kwong, Kristen, Sahu, Pushpendra K., Fajardo, Drew A., Pan, Yue, Horlbeck, Max A., Weissman, Jonathan S., Gustafson, W. Clay, Bivona, Trever G., Sabnis, Amit J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9746907/
https://www.ncbi.nlm.nih.gov/pubmed/36282590
http://dx.doi.org/10.1172/jci.insight.162207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9746907/
https://www.ncbi.nlm.nih.gov/pubmed/36282590
http://dx.doi.org/10.1172/jci.insight.162207

Ejemplares similares