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HIF1 inhibitor acriflavine rescues early-onset preeclampsia phenotype in mice lacking placental prolyl hydroxylase domain protein 2

Preeclampsia is a serious pregnancy disorder that lacks effective treatments other than delivery. Improper sensing of oxygen changes during placentation by prolyl hydroxylases (PHDs), specifically PHD2, causes placental hypoxia-inducible factor-1 (HIF1) buildup and abnormal downstream signaling in e...

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Detalles Bibliográficos
Autores principales:	Sallais, Julien, Park, Chanho, Alahari, Sruthi, Porter, Tyler, Liu, Ruizhe, Kurt, Merve, Farrell, Abby, Post, Martin, Caniggia, Isabella
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9746916/ https://www.ncbi.nlm.nih.gov/pubmed/36227697 http://dx.doi.org/10.1172/jci.insight.158908

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