Metastatic pancreatic neuroendocrine tumors feature elevated T cell infiltration

Pancreatic neuroendocrine tumors (PNETs) are malignancies arising from the islets of Langerhans. Therapeutic options are limited for the over 50% of patients who present with metastatic disease. We aimed to identify mechanisms to remodel the PNET tumor microenvironment (TME) to ultimately enhance su...

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Detalles Bibliográficos
Autores principales: Greenberg, Jacques, Limberg, Jessica, Verma, Akanksha, Kim, David, Chen, Xiang, Lee, Yeon J., Moore, Maureen D., Ullmann, Timothy M., Thiesmeyer, Jessica W., Loewenstein, Zachary, Chen, Kevin J., Egan, Caitlin E., Stefanova, Dessislava, Bareja, Rohan, Zarnegar, Rasa, Finnerty, Brendan M., Scognamiglio, Theresa, Du, Yi-Chieh Nancy, Elemento, Olivier, Fahey, Thomas J., Min, Irene M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9746918/
https://www.ncbi.nlm.nih.gov/pubmed/36301668
http://dx.doi.org/10.1172/jci.insight.160130

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