Increased CHCHD2 expression promotes liver fibrosis in nonalcoholic steatohepatitis via Notch/osteopontin signaling

Nonalcoholic steatohepatitis (NASH) is closely related to liver fibrosis. The role of coiled-coil-helix-coiled-coil-helix domain-containing 2 (CHCHD2) in NASH remains unknown. CHCHD2’s functions as a transcription factor have received much less attention than those in mitochondria. Herein, we system...

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Detalles Bibliográficos
Autores principales: Li, Yue, Xiu, Wenjing, Xu, Jingwen, Chen, Xiangmei, Wang, Guangyan, Duan, Jinjie, Sun, Lei, Liu, Ben, Xie, Wen, Pu, Guangyin, Wang, Qi, Wang, Chunjiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9746920/
https://www.ncbi.nlm.nih.gov/pubmed/36477358
http://dx.doi.org/10.1172/jci.insight.162402

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