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Role of non-coding RNAs as biomarkers and the application of omics technologies in Alzheimer's disease (Review)
Alzheimer's disease (AD) is a neurodegenerative disorder that has a significant association with age. Despite its increasing incidence in the population, the etiology of the disease remains poorly understood, and there are currently no effective treatments readily available. The main genes that...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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D.A. Spandidos
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9747195/ https://www.ncbi.nlm.nih.gov/pubmed/36453246 http://dx.doi.org/10.3892/ijmm.2022.5208 |
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author | Pierouli, Katerina Papakonstantinou, Eleni Papageorgiou, Louis Diakou, Io Mitsis, Thanasis Dragoumani, Konstantina Spandidos, Demetrios A. Bacopoulou, Flora Chrousos, George P. Goulielmos, George N. Eliopoulos, Elias Vlachakis, Dimitrios |
author_facet | Pierouli, Katerina Papakonstantinou, Eleni Papageorgiou, Louis Diakou, Io Mitsis, Thanasis Dragoumani, Konstantina Spandidos, Demetrios A. Bacopoulou, Flora Chrousos, George P. Goulielmos, George N. Eliopoulos, Elias Vlachakis, Dimitrios |
author_sort | Pierouli, Katerina |
collection | PubMed |
description | Alzheimer's disease (AD) is a neurodegenerative disorder that has a significant association with age. Despite its increasing incidence in the population, the etiology of the disease remains poorly understood, and there are currently no effective treatments readily available. The main genes that are associated with AD are the amyloid precursor protein, presenilin-1 and presenilin-2, as well as the apolipoprotein E gene. In addition to genetic factors, a wide range of environmental and lifestyle factors are equally characterized as risk factors for the development of AD, while non-coding RNAs (ncRNAs) and other epigenetic mechanisms play a key role in their detrimental effects. Multiple types of ncRNAs, such as microRNAs, circular RNAs, Piwi-interacting RNAs and long non-coding RNAs are being increasingly implicated in AD. Alterations in ncRNAs can be detected in cerebrospinal fluid, as well in as the brain, highlighting these as promising biomarkers for the detection and treatment of AD. Developments in high-throughput technologies have led to the so-called 'omics' era, which involves the collection of big data and information at both molecular and protein levels, while combining the development of novel computational and statistical tools capable of analyzing and filtering such data. The present review discusses the role of ncRNAs and their use as biomarkers for AD, and summarizes the findings from the application of omics technologies in AD. |
format | Online Article Text |
id | pubmed-9747195 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-97471952022-12-21 Role of non-coding RNAs as biomarkers and the application of omics technologies in Alzheimer's disease (Review) Pierouli, Katerina Papakonstantinou, Eleni Papageorgiou, Louis Diakou, Io Mitsis, Thanasis Dragoumani, Konstantina Spandidos, Demetrios A. Bacopoulou, Flora Chrousos, George P. Goulielmos, George N. Eliopoulos, Elias Vlachakis, Dimitrios Int J Mol Med Articles Alzheimer's disease (AD) is a neurodegenerative disorder that has a significant association with age. Despite its increasing incidence in the population, the etiology of the disease remains poorly understood, and there are currently no effective treatments readily available. The main genes that are associated with AD are the amyloid precursor protein, presenilin-1 and presenilin-2, as well as the apolipoprotein E gene. In addition to genetic factors, a wide range of environmental and lifestyle factors are equally characterized as risk factors for the development of AD, while non-coding RNAs (ncRNAs) and other epigenetic mechanisms play a key role in their detrimental effects. Multiple types of ncRNAs, such as microRNAs, circular RNAs, Piwi-interacting RNAs and long non-coding RNAs are being increasingly implicated in AD. Alterations in ncRNAs can be detected in cerebrospinal fluid, as well in as the brain, highlighting these as promising biomarkers for the detection and treatment of AD. Developments in high-throughput technologies have led to the so-called 'omics' era, which involves the collection of big data and information at both molecular and protein levels, while combining the development of novel computational and statistical tools capable of analyzing and filtering such data. The present review discusses the role of ncRNAs and their use as biomarkers for AD, and summarizes the findings from the application of omics technologies in AD. D.A. Spandidos 2022-11-24 /pmc/articles/PMC9747195/ /pubmed/36453246 http://dx.doi.org/10.3892/ijmm.2022.5208 Text en Copyright: © Pierouli et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Pierouli, Katerina Papakonstantinou, Eleni Papageorgiou, Louis Diakou, Io Mitsis, Thanasis Dragoumani, Konstantina Spandidos, Demetrios A. Bacopoulou, Flora Chrousos, George P. Goulielmos, George N. Eliopoulos, Elias Vlachakis, Dimitrios Role of non-coding RNAs as biomarkers and the application of omics technologies in Alzheimer's disease (Review) |
title | Role of non-coding RNAs as biomarkers and the application of omics technologies in Alzheimer's disease (Review) |
title_full | Role of non-coding RNAs as biomarkers and the application of omics technologies in Alzheimer's disease (Review) |
title_fullStr | Role of non-coding RNAs as biomarkers and the application of omics technologies in Alzheimer's disease (Review) |
title_full_unstemmed | Role of non-coding RNAs as biomarkers and the application of omics technologies in Alzheimer's disease (Review) |
title_short | Role of non-coding RNAs as biomarkers and the application of omics technologies in Alzheimer's disease (Review) |
title_sort | role of non-coding rnas as biomarkers and the application of omics technologies in alzheimer's disease (review) |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9747195/ https://www.ncbi.nlm.nih.gov/pubmed/36453246 http://dx.doi.org/10.3892/ijmm.2022.5208 |
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