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Neurosteroid Activation of GABA-A Receptors: A Potential Treatment Target for Symptoms in Primary Biliary Cholangitis?

BACKGROUND AND AIMS: A third of patients with primary biliary cholangitis (PBC) experience poorly understood cognitive symptoms, with a significant impact on quality of life (QOL), and no effective medical treatment. Allopregnanolone, a neurosteroid, is a positive allosteric modulator of gamma-amino...

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Detalles Bibliográficos
Autores principales:	Wetten, Aaron, Ogle, Laura, Mells, George, Hegade, Vinod S., Jopson, Laura, Corrigan, Margaret, Palmer, Jeremy, Johansson, Maja, Bäckström, Torbjörn, Doverskog, Magnus, Jones, David E. J., Dyson, Jessica K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9747297/ https://www.ncbi.nlm.nih.gov/pubmed/36523650 http://dx.doi.org/10.1155/2022/3618090

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