Intranasal delivery of darunavir improves brain drug concentrations in mice for effective HIV treatment

Despite the availability of combined antiretroviral therapy (cART), which reduces the HIV replication in chronically HIV-infected patients, HIV associated neurocognitive disorders (HAND) persists in the brain. The blood-brain barrier (BBB) is the major barrier for the penetration of drugs including...

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Detalles Bibliográficos
Autores principales: Kumar, Asit, Zhou, Lina, Godse, Sandip, Sinha, Namita, Ma, Dejian, Parmar, Keyur, Kumar, Santosh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9747527/
https://www.ncbi.nlm.nih.gov/pubmed/36532875
http://dx.doi.org/10.1016/j.bbrep.2022.101408

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9747527/
https://www.ncbi.nlm.nih.gov/pubmed/36532875
http://dx.doi.org/10.1016/j.bbrep.2022.101408

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