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Role of poly(ADP-ribose) polymerase-1 in regulating human islet cell differentiation
Poly(ADP-ribose) polymerase-1 (PARP1), a fundamental DNA repair enzyme, is known to regulate β cell death, replication, and insulin secretion. PARP1 knockout (KO) mice are resistant to diabetes, while PARP1 overactivation contributes to β cell death. Additionally, PARP1 inhibition (PARPi) improves d...
Autores principales: | Dadheech, Nidheesh, Srivastava, Abhay, Shah, Rashmi G., Shah, Girish M., Gupta, Sarita |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9747708/ https://www.ncbi.nlm.nih.gov/pubmed/36513699 http://dx.doi.org/10.1038/s41598-022-25405-w |
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