Role of poly(ADP-ribose) polymerase-1 in regulating human islet cell differentiation

Poly(ADP-ribose) polymerase-1 (PARP1), a fundamental DNA repair enzyme, is known to regulate β cell death, replication, and insulin secretion. PARP1 knockout (KO) mice are resistant to diabetes, while PARP1 overactivation contributes to β cell death. Additionally, PARP1 inhibition (PARPi) improves d...

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Detalles Bibliográficos
Autores principales: Dadheech, Nidheesh, Srivastava, Abhay, Shah, Rashmi G., Shah, Girish M., Gupta, Sarita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9747708/
https://www.ncbi.nlm.nih.gov/pubmed/36513699
http://dx.doi.org/10.1038/s41598-022-25405-w

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